#MathOnco Issue 89: interactive sims; evolution/ecology of cancer; phylogenetic inferences; vascularized tumors; spatial structure.
This week in
Math Oncology
Oct. 31, 2019 ~ Issue 89
From the editor
Hello!
Today's topics include evolution and ecology of cancer, phylogenetic inferences, vascularized tumors, and spatial structure. I encourage you to click on the blog post by Rasmus Pedersen on the benefits of building interactive simulations. It includes a really neat interactive example using p5js!
Please enjoy!
-Jeffrey West
PS. I will be away on travel for a bit, so the newsletter will be on a short break! Can I ask a favor? If you publish anything within the next few weeks, please email me a link directly, as I am more likely to miss it while I'm away. Thanks!
#MathOnco Publications
Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer
Authors: Sidra Nawaz, Nicholas A. Trahearn, Andreas Heindl, Susana Banerjee, Carlo C. Maley, Andrea Sottoriva, Yinyin Yuan
Key challenges facing data-driven multicellular systems biology
Authors: Paul Macklin
Molecular biology and evolution of cancer: from discovery to action
Authors: Jason A Somarelli, Heather Gardner, Vincent L Cannataro, Ella F Gunady, Amy M Boddy, ..., Sudhir Kumar, Alex Dornburg, James DeGregori, Jeffrey P Townsend
Mathematical analysis of the Cancitis model and the role of inflammation in blood cancer progression
Authors: Zamra Sajid, Morten Andersen, Johnny T. Ottesen
Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
Authors: Jacob G Scott, Philip K Maini, Alexander R A Anderson, Alexander G Fletcher
#MathOnco Preprints
Modelling the emergence of phenotypic heterogeneity in vascularised tumours
Authors: Chiara Villa, Mark A. J. Chaplain, Tommaso Lorenzi
Mutant evolution in spatially structured and fragmented populations
Authors: Dominik Wodarz, Natalia L Komarova
The benefits of building and working with interactive simulations
Interactive simulations for better model intuition
Rasmus Kristoffer Pedersen: "Communicating scientific results remains a major challenge within any field, whether it is physics, medicine or mathematics. This is particularly the case for mathematical oncology, as mathematical results has to be disseminated clearly to medical collaborators. Understanding the significance of a particular mathematical result can be influential when clinical decisions are made. In this blogpost, I will discuss a way to build intuition about a model and to get a feel for model behaviour, namely through the development of interactive simulations."
#MathOnco - Book of the month
The Maths of Life and Death
Kit Yates: "In this eye-opening and extraordinary book, Yates explores the true stories of life-changing events in which the application - or misapplication - of mathematics has played a critical role: patients crippled by faulty genes and entrepreneurs bankrupted by faulty algorithms; innocent victims of miscarriages of justice and the unwitting victims of software glitches. We follow stories of investors who have lost fortunes and parents who have lost children, all because of mathematical misunderstandings."
Most clicked links of September
Systems biology approaches to measure and model phenotypic heterogeneity in cancer
Modeling genetic heterogeneity of drug response and resistance in cancer
A Monte Carlo method to estimate cell population heterogeneity
Jobs
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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