#MathOnco Issue 90: rapid cancer evolution, clonal selection, mutator models, neoantigen heterogeneity, and parameter identifiability.
This week in
Math Oncology
Nov. 21, 2019 ~ Issue 90
From the editor
Hello!
After a brief hiatus, the math oncology newsletter is back! Today's topics include papers on rapid cancer evolution, clonal selection, mutator models, neoantigen heterogeneity, and parameter identifiability.
Please enjoy!
-Jeffrey West
#MathOnco Publications
Rapid evolution and biogeographic spread in a colorectal cancer
Authors: Joao M. Alves, Sonia Prado-López, José Manuel Cameselle-Teijeiro & David Posada
Modeling tumor evolutionary dynamics to predict clinical outcomes for patients with metastatic colorectal cancer: a retrospective analysis
Authors: Jiawei Zhou, Yutong Liu, Yubo Zhang, Quefeng Li and Yanguang Cao
Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
Authors: Priyanka Gopal, Elif Irem Sarihan, Eui Kyu Chie, Gwendolyn Kuzmishin, ..., Thomas R. Gildea, Craig D. Peacock, Drew J. Adams & Mohamed E. Abazeed
Parallel Causation in Oncogenic and Anthropogenic Degradation and Extinction
Authors: James DeGregori, Niles Eldredge
Model genotype–phenotype mappings and the algorithmic structure of evolution
Authors: Daniel Nichol, Mark Robertson-Tessi, Alexander R. A. Anderson and Peter Jeavons
Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity
Authors: Franck Raynaud, Marco Mina, Giovanni Ciriello
#MathOnco Preprints
Parameter identifiability analysis for spatiotemporal models of cell invasion
Authors: Matthew J Simpson, Ruth E Baker, Sean T Vittadello, Oliver J Maclaren
Tumor neoantigen heterogeneity thresholds provide a time window for combination immunotherapy
Authors: Guim Aguadé-Gorgorió, Ricard Solé
A mathematical dissection of the adaptation of cell populations to fluctuating oxygen levels
Authors: Aleksandra Ardaševa, Robert A Gatenby, Alexander R A Anderson, Helen M Byrne, Philip K Maini, Tommaso Lorenzi
Variation in the life history strategy of cells underlies tumor’s functional diversity
Authors: Tao Li, Jialin Liu, Jing Feng, Zhenzhen Liu, Sixue Liu, Minjie Zhang, Yuezheng Zhang, Yali Hou, Dafei Wu, Chunyan Li, Young-Bin Chen, Chung-I Wu, Hua Chen, Xuemei Lu
A long and winding R0(ad)1
Jacob Scott: "At the end of my third year as a PI at the Cleveland Clinic Lerner Research Institute, and many submissions of large and small grants to support my mathematical oncology group, I am ecstatic to tell you about the R01 that was funded through the NCI (and the MABS study section)."
#MathOnco - Book of the month
The Art of Theoretical Biology
Franziska Matthäus, Sebastian Matthäus, Sarah Harris, Thomas Hillen: "This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision."
Most clicked links of October
Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
Key challenges facing data-driven multicellular systems biology
On measuring selection in cancer from subclonal mutation frequencies
Jobs
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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