#MathOnco Issue 93: uncertainty/sensitivity in agent-based models; transmissible cancer "speciation"; fluid mechanics review in cancer; evolution
This week in
Math Oncology
Dec. 12, 2019 ~ Issue 93
From the editor
Hello!
Today I've included some links on evolutionary ideas, including an interesting Quanta article on transmissible cancer "speciation." There's also links to a fluid mechanics review in cancer, a really great preprint on uncertainty/sensitivity in agent-based models.
In fact, many of the articles combine agent-based approaches with evolutionary thinking. Cool!
'Tis the season for job postings lately! Here's another one for a postdoc in Sebastien Benzekry's group (immunotherapy in non-small cell lung cancer).
Please enjoy!
-Jeffrey West
#MathOnco Publications
Eradicating metastatic cancer and the eco-evolutionary dynamics of Anthropocene extinctions
Authors: Robert A Gatenby, Yael Artzy-Randrup, Tamir Epstein, Damon R Reed and Joel S Brown
Fluids and their mechanics in tumour transit: shaping metastasis
Authors: Gautier Follain, David Herrmann, Sébastien Harlepp, Vincent Hyenne, Naël Osmani, Sean C. Warren, Paul Timpson & Jacky G. Goetz
#MathOnco Preprints
Uncertainty and Sensitivity Analyses Methods for Agent-Based Mathematical Models: An Introductory Review
Authors: Sara Hamis, Stanislav Stratiev, Gibin G Powathil
Targeting Cellular DNA Damage Responses: Predicting in vivo treatment responses using an in vitro-calibrated agent-based mathematical model
Authors: Sara Hamis, James Yates, Mark AJ Chaplain, Gibin G Powathil
Combining Hypoxia-Activated Prodrugs and Radiotherapy in silico: Impact of Treatment Scheduling and the Intra-Tumoural Oxygen Landscape
Authors: Sara Hamis, Mohammad Kohandel, Ludwig J Dubois, Ala Yaromina, Philippe Lambin, Gibin G Powathil
Measurement and models accounting for cell death capture hidden variation in compound response
Authors: Song Yi Bae, Ning Guan, Rui Yan, Katrina Warner, Aaron S Meyer
Controlling the speed and trajectory of evolution with counterdiabatic driving
Authors: Shamreen Iram, Emily Dolson, Joshua Chiel, Julia Pelesko, Nikhil Krishnan, Özenç Güngör, Benjamin Kuznets-Speck, Sebastian Deffner, Efe Ilker, Jacob G. Scott, Michael Hinczewski
Mechanical cell competition in heterogeneous epithelial tissues
Authors: Ryan J Murphy, Pascal R Buenzli, Ruth E Baker, Matthew J Simpson
Can New Species Evolve From Cancers? Maybe. Here’s How.
Christie Wilcox: "Researchers agree it’s a long shot, but transmissible cancers could theoretically evolve into independent species. Certain weird parasites might be living proof."
#MathOnco - Book of the month
The Art of Theoretical Biology
Franziska Matthäus, Sebastian Matthäus, Sarah Harris, Thomas Hillen: "This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision."
Most clicked links of Oct/Nov
Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
Dynamics of tumor growth: chemotherapy and integrative oncology
Key challenges facing data-driven multicellular systems biology
On measuring selection in cancer from subclonal mutation frequencies
Jobs
NEW: Pre-leukemic Dynamics – MSc or PhD Studentship (Morgan Craig)
Quantitative Systems Pharmacology (QSP) Modeler - Cell Therapy (Dean Bottino)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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