#MathOnco Issue 18: crowd sourcing cancer treatment, gene regulatory networks, ising models, SNPs, fitness landscape, Monte Carlo
This week in
Mathematical Oncology
May 10, 2018 ~ Issue 18
From the editor
Today's most exciting bit of news is the release of a new mobile game app designed to crowd source cancer treatment optimizations -- built on the foundation of a #MathOnco model. Here's a description for the game, Cancer Crusade:
You are a doctor from the future. With your Treatment Simulator, you can fight back against even the roughest cancer invasions. Design a custom treatment schedule for each virtual patient. The treatment schedules you design will be sent to researchers at Moffitt Cancer Center to help discover new strategies. Good luck, doctor!
In other news, several interesting gene-regulatory-network models (here, here) were released, along with a fascinating Ising model using "Go" gaming as a metaphor. You'll also find relevant discussions on fitness: Waddington's epigentic landscape models along with a model of partial fitness orders and genetic interactions.
Enjoy,
-Jeffrey West
#MathOnco Publications
Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism
Authors: Sabine Hummert, Christina Glock, Stefan N. Lang, Christian Hummert, ..., Stefan Schuster
Cancer growth and metastasis as a metaphor of Go gaming: an Ising model approach
Authors: Didier Barradas-Bautistia, Matias Alvarado-Mentado, Mark Agostino, Germinal Cocho
The geometry of partial fitness orders and an efficient method for detecting genetic interactions
Authors: Catlin Lienkaemper, Lisa Lamberti, James Drain, Niko Beerenwinkel, Alex Gavryushkin
Topological and statistical analyses of gene regulatory networks reveal unifying yet quantitatively different emergent properties
Authors: Wilberforce Zachary Ouma, Katja Pogacar, Erich Grotewold
#MathOnco Preprints
Cancer stem cells modulate patterns and processes of evolution in cancers
Authors: Lucie Laplane
A Monte Carlo method for in silico modeling and visualization of Waddington's epigenetic landscape with intermediate details
Authors: Xiaomeng Zhang, Ket Hing Chong, Jie Zheng
The mechanisms of gene regulatory networks constrain evolution: a lesson from synthetic circuits
Authors: Yolanda Schaerli, Alba Jimenez, Jose M. Duarte, ..., Andreas Wagner
Criticality in tumor evolution and clinical outcomes
Authors: Erez Persi, Yuri I Wolf, Mark Leiserson, Eugene V Koonin, Eytan Ruppin
#MathOnco News
Cancer Crusade
Rafael Bravo: "What if you could have fun gaming while helping cancer researchers find new methods of applying treatments? Welcome to the crowd-sourcing revolution of tomorrow's oncology innovations."
Download the Android or iOS version today, or find more information at cancercrusadegame.com.
#MathOnco Books
The Cancer Chronicles
"When the woman he loved was diagnosed with a metastatic cancer, George Johnson set out to learn everything he could about the disease and the people who spend their careers trying to understand and to fight it.
Johnson’s deceptively casual narrative route is cannily chosen. He wanders everywhere, an intelligent, skeptical, interested and saddened observer. "
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