#MathOnco Issue 107: chemo evolution, deleterious mutations, evolutionary therapy, a framework for hybrid modeling, and more
This week in
Math Oncology
Mar. 19, 2020 ~ Issue 107
From the editor
Hello!
Today's issue of "This week in Mathematical Oncology" is packed with all sorts of interesting models! There are publications on: chemo evolution, deleterious mutations, evolutionary therapy, a framework for hybrid modeling, and more.
Enjoy!
-Jeffrey West
#MathOnco Publications
Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization
Authors: Rafael R. Bravo, Etienne Baratchart, Jeffrey West, Ryan O. Schenck, Anna K. Miller, Jill Gallaher, Chandler D. Gatenbee, David Basanta, Mark Robertson-Tessi, Alexander R. A. Anderson
A plausible accelerating function of intermediate states in cancer metastasis
Authors: Hanah Goetz, Juan R. Melendez-Alvarez, Luonan Chen, Xiao-Jun Tian
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Authors: Saioa López, Emilia L. Lim, Stuart Horswell, Kerstin Haase, ..., Mariam Jamal-Hanjani, TRACERx Consortium, Charles Swanton, Nicholas McGranahan
An evolutionary framework for treating pediatric sarcomas
Authors: Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, ..., Lars M. Wagner, Mark G. Alexandrow, Robert A. Gatenby, Joel S. Brown
Efficiency of cancer treatments: in silico experiments
Authors: Elena Piretto, Marcello Delitala, Mario Ferraro
Discrete and continuum phenotype-structured models for the evolution of cancer cell populations under chemotherapy
Authors: Rebecca E.A. Stace, Thomas Stiehl, Mark A.J. Chaplain, Anna Marciniak-Czochra, Tommaso Lorenzi
Impact of tumour size measurement inter-operator variability on model-based drug effect evaluation
Authors: Aurélie Lombard, Hitesh Mistry, Sonya C. Chapman, Ivelina Gueoguieva, Leon Aarons, Kayode Ogungbenro
#MathOnco Preprints
Mathematically Modeling Inflammation as a Promoter of Tumour Growth
Authors: Kathleen P Wilkie, Farjana Aktar
Spontaneous Cell Fusions as a Mechanism of Parasexual Recombination in Tumor Cell Populations
Authors: Daria Myroshnychenko, Etienne Baratchart, Meghan Ferrall-Fairbanks, Robert Vander Velde, ..., Marilyn Bui, Philipp M Altrock, David Basanta, Andriy Marusyk
IMO Workshop - A History
The Mathematical Oncology Blog
Sandy Anderson: "This year IMO will run its 10th annual workshop. 10 years is quite an achievement by most academic metrics, so I thought it was long overdue to have a dedicated IMO Workshop website and Twitter handle @imoworkshop. The workshop and the way that IMO specifically runs them has evolved over the course of the decade and the idea for this type of workshop actually started before IMO even began. So before you plunge into all of the cool questions, presentations and specific aims catalogued on this site, please take a little time to read how we ended up at this point."
Read more about the workshop on
the dedicated IMO workshop website.
#MathOnco - Book of the month
Tales of Impossibility: The 2000-Year Quest to Solve the Mathematical Problems of Antiquity
David S Richeson: "Tales of Impossibility recounts the intriguing story of the so-called problems of antiquity, four of the most famous and studied questions in the history of mathematics. First posed by the ancient Greeks, these compass and straightedge problems—squaring the circle, trisecting an angle, doubling the cube, and inscribing regular polygons in a circle—have served as ever-present muses for mathematicians for more than two millennia. David Richeson follows the trail of these problems to show that ultimately, their proofs—demonstrating the impossibility of solving them using only a compass and straightedge—depended upon and resulted in the growth of mathematics."
Jobs
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Postdoctoral Fellow in Mathematical Oncology (Russell Rockne)
Pre-leukemic Dynamics – MSc or PhD Studentship (Morgan Craig)
Quantitative Systems Pharmacology (QSP) Modeler - Cell Therapy (Dean Bottino)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
Do you see something we missed? Reply to this email to send us an idea for next week's issue.
The #MathOnco newsletter is maintained by Jeffrey West.
If you were forwarded this email, subscribe for free here to get it delivered every week.