#MathOnco Issue 116: collateral sensitivity, stromal reactivity, acquired resistance, cure vs containment, drug synergy, neutral syndrome
This week in
Math Oncology
May 21, 2020 ~ Issue 116
From the editor
Dear Readers,
On this week's long list of impressive articles: collateral sensitivity, stromal reactivity, acquired resistance, cure vs containment, drug synergy, and also a perspective on the "neutral syndrome" that has infected much of evolutionary modeling lately.
I've also included links to two blog posts: one on the Dartmouth semester internship at Moffitt, and another on the interesting initiative to provide public review of preprints at eLife.
Enjoy,
-Jeffrey West
#MathOnco Publications
Cancer therapy: attempt cure or manage drug resistance?
Authors: Elsa Hansen, Andrew F. Read
An in silico model of LINE-1-mediated neoplastic evolution
Authors: Jack LeBien, Gerald McCollam, Joel Atallah
Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Authors: Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, ..., Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk
Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression
Authors: Ziv Frankenstein, David Basanta, Omar E. Franco, Yan Gao, ..., Min Jae Lee, Simon W. Hayward, Gustavo Ayala, Alexander R. A. Anderson
State-transition analysis of time-sequential gene expression identifies critical points that predict development of acute myeloid leukemia
Authors: Russell C Rockne, Sergio Branciamore, Jing Qi, David E Frankhouser, ..., Stephen Forman, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci
Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations
Authors: Elsa Hansen, Jason Karslake, Robert J. Woods, Andrew F. Read, Kevin B. Wood
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer
Authors: Jennifer Y. Ge, Shaokun Shu, Mijung Kwon, Bojana Jovanović, ..., Thomas O. McDonald, David Pellman, Franziska Michor, Kornelia Polyak
Neutral syndrome
Authors: Armand M. Leroi, Ben Lambert, James Rosindell, Xiangyu Zhang, Giorgos D. Kokkoris
#MathOnco Preprints
The role of synergy and antagonism in designing multidrug adaptive chemotherapy schedules
Authors: Paul Newton, Yongqian Ma
Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells
Authors: Vince Kornél Grolmusz, Jinfeng Chen, Rena Emond, Patrick A. Cosgrove, Lance Pflieger, Aritro Nath, Philip J. Moos, Andrea H. Bild
Math A ‘Common Denominator’ for College Students
Moffitt Cancer Center
Kim Polacek: "When you get off the elevator on the fourth floor of Moffitt Cancer Center’s Vincent A. Stabile Research Building, you’re greeted with the aroma of fresh coffee. Take a few steps into the office suite, and you’ll find a room full of chalkboards and well-caffeinated mathematicians scribbling equations everywhere. You may wonder why a cancer center would have a department full of mathematicians, but the addition of mathematical concepts and modeling to cancer research has resulted in better treatment strategies for patients."
New from eLife: Invitation to submit to Preprint Review
eLife: "Authors can now request peer review without being evaluated for publication in eLife up front. The explosion of COVID-related papers on bioRxiv and medRxiv demonstrates the important role author-driven publications (preprints) can have in accelerating science. But it also highlights the need for an organised system to provide feedback and scrutiny of preprints."
#MathOnco - Book of the month
The Art of Theoretical Biology
Franziska Matthäus, Sebastian Matthäus, Sarah Harris, Thomas Hillen: "This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision."
Jobs
NEW: Mathematical modelling of cancer ecology and evolution – PhD Studentships (Rob Noble)
NEW: Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
NEW: Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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