#MathOnco Issue 19: mutational processes; spatial mutation patterns; epithelial-mesenchymal transition; Erythropoiesis; bipartite ecological networks
This week in
Mathematical Oncology
May 17, 2018 ~ Issue 19
From the editor
At times, the mathematical oncology articles seem to pile into an avalanche week, so let's get straight to the science! Models of mutational processes of driver selection and spatial mutation patterns were released, along with a mechanistic model of epithelial-mesenchymal transition. I also included non-cancer models of Erythropoiesis and ecological networks, to learn nice approaches in tangential fields.
Enjoy,
-Jeffrey West
#MathOnco Publications
Inferring parsimonious migration histories for metastatic cancers
Authors: Mohammed El-Kebir, Gryte Satas, Benjamin J. Raphael
Spatial mutation patterns as markers of early colorectal tumor cell mobility
Authors: Marc D. Ryser, Byung-Hoon Min, Kimberly D. Siegmund, Darryl Shibata
The effects of mutational processes and selection on driver mutations across cancer types
Authors: Daniel Temko, Ian PM Tomlinson, Simone Severini, Benjamin Schuster-Bockler, Trevor A Graham
A computational framework for the personalized clinical treatment of glioblastoma multiforme
Authors: Abramo Agosti, Clara Cattaneo, Chiara Giverso, Davide Ambrosi, Pasquale Ciarletta
#MathOnco Preprints
A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling
Authors: Federico Bocci, Mohit Kumar Jolly, Jason George, Herbert Levine, Jose Nelson Onuchic
Tuning spatial profiles of selection pressure to modulate the evolution of resistance
Authors: Maxwell G. De Jong, Kevin B. Wood
Density-dependent selection and the limits of relative fitness
Authors: Jason Bertram, Joanna Masel
Uncovering indirect interactions in bipartite ecological networks
Authors: Benno I Simmons, Alyssa Cirtwill, Nick Baker, Lynn V Dicks, Daniel B Stouffer, William J Sutherland
Optimal point process filtering for birth-death model estimation
Authors: Kris Varun Parag, Oliver Pybus
Calibration, selection and identifiability analysis of a mathematical model of the in vitro Erythropoiesis in normal and perturbed contexts
Authors: Ronan Duchesne, Anissa Guillemin, Olivier Gandrillon, Fabien Crauste
Prioritizing network communities
Authors: Marinka Zitnik, Rok Sosic, Jure Leskovec
#MathOnco News
Adaptive Oncogenesis Podcast Interview
James DeGregori: "Dr. James DeGregori, deputy director of the University of Colorado Cancer Center, discusses with host Susan Moran his new theory–one that challenges conventional wisdom–about why and how we get cancer. In his new book, called Adaptive Oncogenesis: A New Understanding of How Cancer Evolves Inside Us."
Cancer Crusade
Rafael Bravo: What if you could have fun gaming while helping cancer researchers find new methods of applying treatments? Welcome to the crowd-sourcing revolution of tomorrow's oncology innovations. Download the Android or iOS version today, or find more information at cancercrusadegame.com.
#MathOnco Books
Evolutionary Medicine
"This book is a gem of a textbook about the principles of evolutionary thinking and the relevance of evolutionary biology to clinical medicine. The authors draw upon decades of experience teaching medical students at Yale, with interesting examples, including experimental observations in other species."
Stearns, Medzhitov
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