#MathOnco Issue 22: negative selection; passenger mutations; tumor evolution; generalized formalisms; natural selection; model simplification
This week in
Mathematical Oncology
June 15, 2018 ~ Issue 22
From the editor
As always, welcome to our new subscribers! I'm thankful for the several of you who sent suggestions of articles to include in this week's edition of the #mathonco newsletter -- thanks for finding some real modeling gems.
These include the role of negative selection and passenger mutations in tumor evolution, a generalized formalism for natural selection, and an interesting exercise on model simplification and control dynamics.
Happy Friday,
-Jeffrey West
#MathOnco Publications
Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
Authors: Luis Zapata, Oriol Pich, Luis Serrano, Fyodor A Kondrashov, Stephan Ossowski, Martin H Schaefer
Games with resources and their use in modeling effects of anticancer treatment
Authors: Andrzej Swierniak, Michal Krzeslak, Damian Borys
A new method for shrinking tumor based on microenvironmental factors: introducing a stochastic agent-based model of avascular tumor growth
Authors: SH Sabzpoushan, Fateme Pourhasanzade
Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution
Authors: Dominik Wodarz, Alan C. Newell, Natalia L. Komarova
#MathOnco Preprints
Parameter estimation and treatment optimization in a stochastic model for immunotherapy of cancer
Authors: Modibo Diabate, Loren Coquille, Adeline Samson
Combination of direct methods and homotopy in numerical optimal control: application to the optimization of chemotherapy in cancer
Authors: Antoine Olivier, Camille Puchol
A mathematical formalism for natural selection with arbitrary spatial and genetic structure
Authors: Benjamin Allen, Alex McAvoy
#MathOnco News
The physics of glass opens a window into biology
Jordana Cepelewicz: "She took inspiration from the dynamics of glasses, those disordered solid materials that resemble fluids in their behavior. Manning found that the tissues in our bodies behave in many of the same ways. As a result, with insights gleaned from the physics of glasses, she has been able to model the mechanics of cellular interactions in tissues, and uncover their relevance to development and disease."
#MathOnco - Book of the month
Adaptive Oncogenesis
James DeGregori's new cell biology book "corrects the fundamental attribution error that has focused cancer research on malignant cells and their genes. Adaptive oncogenesis, or ‘EcoOncogenesis,’ shows that the ecosystems surrounding cells are equally important, responsible for creating selection forces that speed or slow the evolution of cancer. "
#MathOnco - Best of last month
Most clicked links of May
Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer
A computational framework for the personalized clinical treatment of glioblastoma multiforme
Estimating intratumoral heterogeneity from spatiotemporal data
Do you see something we missed? Click the submit button below to send us an idea for next week's issue.
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