#MathOnco Issue 25: mechanistic models vs machine learning; eco-evolution; combinatorial immunotherapies; physical interactions
This week in
Mathematical Oncology
July 5, 2018 ~ Issue 25
From the editor
In case you missed it, be sure to check out the updated "most clicked" links of June at the bottom, in no particular order. To those of you attending SMB next week, be sure to tweet or email me any exciting #mathonco research presented there!
-Jeffrey West
#MathOnco Publications
Mechanistic models versus machine learning, a fight worth fighting for the biological community?
Authors: Ruth E. Baker, Jose-Maria Peña, Jayaratnam Jayamohan, Antoine Jérusalem
Eco-evolutionary causes and consequences of temporal changes inintratumoural blood flow
Authors: Robert J. Gillies, Joel S. Brown, Alexander R. A. Anderson & Robert A. Gatenby
Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates
Authors: Benjamin Werner, Andrea Sottoriva
High-throughput screening of combinatorial immunotherapies with patient-specific in silico models of metastatic colorectal cancer
Authors: Jakob Nikolas Kather, Pornpimol Charoentong, Meggy Suarez-Carmona, Esther Herpel, Fee Klupp, Alexis Ulrich, Martin Schneider, Inka Zoernig, Tom Luedde, Dirk Jaeger, Jan Poleszczuk and Niels Halama
#MathOnco Preprints
Disentangling the effects of genetic architecture, mutational bias and selection on evolutionary forecasting
Authors: Peter A Lind, Eric Libby, Jenny Herzog, Paul B Rainey
Molecular phenotyping using networks, diffusion, and topology: soft tissue sarcoma
Authors: James Mathews, Maryam Pouryahya, Caroline Moosmueller, Ioannis Kevrekidis, Joseph Deasy, Allen Tannenbaum
Patterns of tumor progression predict small and tissue-specific tumor-originating niches
Authors: Thomas Buder, Andreas Deutsch, Barbara Klink, Anja Voss-Böhme
Physical interactions reduce the power of natural selection in growing yeast colonies
Authors: Andrea Giometto, David R Nelson, Andrew W Murray
#MathOnco News
Mathematics Shows How to Ensure Evolution
John Rennie: "New results emerging from graph theory prove that the way a population is organized can guarantee the eventual triumph of natural selection — or permanently thwart it."
#MathOnco - Book of the month
Letters to a Young Scientist
Edward O. Wilson: The Pulitzer Prize–winning biologist imparts the wisdom of his storied career to the next generation by threading twenty-one letters with autobiographical anecdotes that illuminate his motivations for becoming a biologist." With section titles like "The Creative Process" or "What is science?" or "Theory and the Big Picture," this emerging classic is sure to interest the scientist young or old.
#MathOnco - Best of last month
Most clicked links of June
Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution
Cancer as a Social Dysfunction - Why Cancer Research Needs New Thinking
Do you see something we missed? Click the submit button below to send us an idea for next week's issue.
The #MathOnco newsletter is maintained by @jeffreyjizzle. If you were forwarded this email, subscribe for free here to get it delivered every week.