#MathOnco Issue 32: maintenance treatment; properties of Wright-Fisher models; Pareto evolutionary trade-offs of driver mutations; ELECTRE methods
This week in
Mathematical Oncology
Aug. 23, 2018 ~ Issue 32
From the editor
Good morning and/or afternoon!
This week in math oncology we have an article in scheduling therapeutics using ELECTRE methods in lung cancer as well an article using maintenance treatment options in leukemia. There's a nice paper on properties of Wright-Fisher models, and a really intriguing preprint on Pareto evolutionary trade-offs of driver mutations. I hope you enjoy!
I'll also wish a hearty welcome to our new subscribers!
-Jeffrey West
#MathOnco Publications
Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
Authors: David Shorthouse, Angela Riedel, Emma Kerr, Luisa Pedro, Dóra Bihary, Shamith Samarajiwa, Carla P. Martins, Jacqueline Shields & Benjamin A. Hall
Therapeutic Schedule Evaluation for Brain-Metastasized Non-Small Cell Lung Cancer with A Probabilistic Linguistic ELECTRE II Method
Authors: Ling Pan, Peijia Ren, Zeshui Xu
Remission maintenance treatment options in chronic lymphocytic leukemia
Authors: Alexander Egle, Lisa Pleyer, Thomas Melchardt, Tanja Nicole Hartmann, Richard Greil
Fitness potentials and qualitative properties of the Wright-Fisher dynamics
Authors: Fabio A. C. C. Chalub, Max O. Souza
#MathOnco Preprints
Universal cancer tasks, evolutionary tradeoffs, and the functions of driver mutations
Authors: Jean Hausser, Pablo Szekely, Noam Bar, Anat Zimmer, Hila Sheftel, Carlos Caldas, Uri Alon
Combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer with CancerInSilico
Authors: Thomas D Sherman, Luciane T Kagohara, Raymon Cao, Raymond Cheng, Matthew Satriano, Michael Considine, Gabriel Krigsfeld, Ruchira Ranaweera, Yong Tang, Sandra Jablonski, Genevieve Stein-O'Brien, Daria Gaykalova, Louis M Weiner, Christine Chung, Elana Fertig
Fixation time in evolutionary graphs: a mean field approach
Authors: Mahdi Hajihashemi jazi, Keivan Aghababaei Samani
Genesis of the αβ T-cell receptor
Authors: Thomas Dupic, Quentin Marcou, Thierry Mora, Aleksandra M Walczak
On the Non-uniqueness of Solutions to the Perfect Phylogeny Mixture Problem
Authors: Dikshant Pradhan and Mohammed El-Kebir
#MathOnco News
Evolution runs faster on shorter timescales
Carrie Arnold: "It’s like Einstein’s theory of relativity, but for viruses,” said Sebastián Duchêne, a computational evolutionary biologist at the University of Melbourne. The time-dependent rate phenomenon says that the speed of an organism’s evolution will depend on the time frame over which the observer is looking at it. And as with relativity, researchers can now calculate by how much.
#MathOnco - Book of the month
Ecology and Evolution of Cancer
B. Ujvari, B. Roche, F. Thomas: "Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field."
#MathOnco - Best of last month
Most clicked links of July
Cancer-causing somatic mutations: they are neither necessary nor sufficient
Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow
Mechanistic models versus machine learning, a fight worth fighting for the biological community?
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