#MathOnco Issue 34: clonal evolution; punctuated equilibrium; 3D genome structure; recurrent jackpot events
This week in
Mathematical Oncology
Sept. 6, 2018 ~ Issue 34
From the editor
Greetings!
At times, it just so happens that a theme emerges while I'm doing the weekly business of gathering these resources. Today's issue contains several interesting articles on evolutionary concepts: punctuated equilibrium in colorectal cancer, a generalized math model of these so-called 'jackpot' events, and a paper on detection of evolution via multi-region sequencing. To that end, I've also included the blog post paired with the first article mentioned and a link to a starter book on these very same evolutionary concepts.
Apologies for the lack of preprints today. It just so happened to be a week of so many great publications!
Enjoy,
-Jeffrey West
#MathOnco Publications
Detecting repeated cancer evolution from multi-region tumor sequencing data
Authors: Giulio Caravagna, Ylenia Giarratano, Daniele Ramazzotti, Ian Tomlinson, Trevor A. Graham, Guido Sanguinetti & Andrea Sottoriva
Three-dimensional genome structures of single diploid human cells
Authors: Longzhi Tan, Dong Xing, Chi-Han Chang, Heng Li, X. Sunney Xie
Evolutionary history of human colitis-associated colorectal cancer
Authors: Ann-Marie Baker, William Cross, Kit Curtius, Ibrahim Al Bakir, Chang-Ho Ryan Choi, ..., Simon J Leedham, Trevor A Graham
Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model
Authors: Yoshimasa Aoto, Kazuhiro Okumura, Tsuyoshi Hachiya, Sumitaka Hase, Yuichi Wakabayashi, Fuyuki Ishikawa & Yasubumi Sakakibara
Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer
Authors: Emilia Kozłowska, Anniina Färkkilä, Tuulia Vallius, Olli Carpén, Jukka Kemppainen, Seija Grénman, Rainer Lehtonen, Johanna Hynninen, Sakari Hietanen and Sampsa Hautaniemi
Topography of cancer-associated immune cells in human solid tumors
Authors: Jakob Nikolas Kather, Meggy Suarez-Carmona, Pornpimol Charoentong, Cleo-Aron Weis, ..., Dirk Jäger, Niels Halama
Selection-Like Biases Emerge in Population Models with Recurrent Jackpot Events
Authors: Oskar Hallatschek
Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
Authors: Khurum H. Khan, David Cunningham, Benjamin Werner, Georgios Vlachogiannis, Inmaculada Spiteri, ..., Andrea Sottoriva and Nicola Valeri
#MathOnco News
Getting a handle on the evolutionary processes of cancer
William Cross: "The most surprising finding of this study came as we build phylogenetic trees from the adenoma sequencing data. In at least three of the nine lesions sampled we found that key driver mutations coexisted across the tissues, meaning that they could not have been acquired sequentially or as selective sweeps in the way that has almost universally been assumed."
#MathOnco - Book of the month
Arrival of the Fittest
Andreas Wagner: "Natural selection can preserve innovations, but it cannot create them. Nature’s many innovations—some uncannily perfect—call for natural principles that accelerate life’s ability to innovate. Darwin’s theory of natural selection explains how useful adaptations are preserved over time. But the biggest mystery about evolution eluded him. As genetics pioneer, Hugo de Vries put it, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest."
#MathOnco - Best of last month
Most clicked links of July
The Genetic/Non-genetic Duality of Drug ‘Resistance’ in Cancer
The Importance of Spatial Randomness in the Evolutionary Dynamics of Mutants
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