#MathOnco Issue 36: competition; fitness valleys, stem cell dynamicss; generalized evolutionary framework; tumor immunity
This week in
Mathematical Oncology
Sept. 20, 2018 ~ Issue 36
From the editor
Greetings fellow Math Onco researchers,
This week's issue has several interesting topics including competition in fitness valleys, stem cell dynamics, and a generalized evolutionary framework. In other news, summer is almost over! That means that SMB published the fall version of their newsletter, in case you missed it!
-Jeffrey West
#MathOnco Publications
Methods for determining key components in a mathematical model for tumor–immune dynamics in multiple myeloma
Authors: Jill Gallaher, Kamila Larripa, Marissa Renardy, ... , Hearn Jay Cho, Helen Moore
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials
Authors: Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria Carla Roncaglioni, Takeshi Morimoto, Ziyah Mehta
Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
Authors: Jakob Hofvander, Björn Viklund, Anders Isaksson, Otte Brosjö, Fredrik Vult von Steyern, Pehr Rissler, Nils Mandahl & Fredrik Mertens
#MathOnco Preprints
SLiM 3: Forward genetic simulations beyond the Wright-Fisher model
Authors: Benjamin C. Haller, Philipp W. Messer
Competing paths over fitness valleys in growing populations
Authors: Benjamin C. Haller, Philipp W. Messer
The Optimal Radiation Dose to Induce Robust Systemic Anti-Tumor Immunity
Authors: Jan Poleszczuk and Heiko Enderling
Statistical and mathematical modeling of spatiotemporal dynamics of stem cells
Authors: Walter de Back, Thomas Zerjatke, Ingo Roeder
A unified, mechanistic framework for developmental and evolutionary change
Authors: Enrico Borriello, Sara I. Walker, Manfred D. Laubichler
#MathOnco News
Google Dataset Search
"In today's world, scientists in many disciplines and a growing number of journalists live and breathe data. There are many thousands of data repositories on the web, providing access to millions of datasets; and local and national governments around the world publish their data as well. To enable easy access to this data, we launched Dataset Search, so that scientists, data journalists, data geeks, or anyone else can find the data required for their work and their stories, or simply to satisfy their intellectual curiosity."
#MathOnco - Book of the month
Arrival of the Fittest
Andreas Wagner: "Natural selection can preserve innovations, but it cannot create them. Nature’s many innovations—some uncannily perfect—call for natural principles that accelerate life’s ability to innovate. Darwin’s theory of natural selection explains how useful adaptations are preserved over time. But the biggest mystery about evolution eluded him. As genetics pioneer, Hugo de Vries put it, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest."
#MathOnco - Best of last month
Most clicked links of August
The Genetic/Non-genetic Duality of Drug ‘Resistance’ in Cancer
The Importance of Spatial Randomness in the Evolutionary Dynamics of Mutants
Do you see something we missed? Click the submit button below to send us an idea for next week's issue.
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