#MathOnco Issue 39: quantifying tumor heterogeneity, drivers/oncogenes/tumor suppressors; population statistics on cancer genomic data.
This week in
Mathematical Oncology
Oct. 11, 2018 ~ Issue 39
From the editor
Today's issue is data rich, with a few publications quantifying tumor heterogeneity, a source for drivers, oncogenes, and tumor suppressors, as well as some population statistics on cancer genomic data.
We've also started a job's listing page (found here) for math oncology-related postdocs, PhD, and faculty positions. They will also be listed at the end of the email. Scroll down to see the news!
Enjoy,
-Jeffrey West
PS. Math onco publications are now in the process of being made searchable!
#MathOnco Publications
Nonidentifiability in Model Calibration and Implications for Medical Decision Making
Authors: Fernando Alarid-Escudero, Richard F. MacLehose, Yadira Peralta, Karen M. Kuntz, Eva A. Enns
The influence of time delay in a chaotic cancer model
Authors: Subhas Khajanchi, Matjaž Perc, and Dibakar Ghosh
Is adaptive therapy natural?
Authors: Frédéric Thomas , Emmanuel Donnadieu, Guillaume M. Charriere, Camille Jacqueline, Aurélie Tasiemski, Pascal Pujol, François Renaud, Benjamin Roche, Rodrigo Hamede, Joel Brown , Robert Gatenby , Beata Ujvari
#MathOnco Preprints
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types
Authors: Stefan C. Dentro, Ignaty Leshchiner, Kerstin Haase, ..., Peter Van Loo, PCAWG Evolution and Heterogeneity Working Group, PCAWG network
Cooperation of partially-transformed clones: the invisible force behind the early stages of carcinogenesis
Authors: Alessandro Esposito
CancerMine: A literature-mined resource for drivers, oncogenes and tumor suppressors in cancer
Authors: Jake Lever, Eric Y Zhao, Jasleen Grewal, Martin R Jones, Steven JM Jones
An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance
Authors: Shengnan Xu, Kathryn E Ware, Yuantong Ding, So Young Kim, Maya Sheth, Sneha Rao, Wesley Chan, Andrew J Armstrong, William C Eward, Mohit K Jolly, Jason A Somarelli
Structured environments fundamentally alter dynamics and stability of ecological communities
Authors: Nick Vallespir Lowery, Tristan Ursell
Population assignment from cancer genome profiling data
Authors: Qingyao Huang, Michael Baudis
Backward evolution from gene network dynamics
Authors: Merzu Kebede Belete, Daniel A Charlebois, Gabor Balazsi
#MathOnco News
Most tumors in body share important mutations
Sharon Reynolds (NIH): “We took samples from multiple untreated metastases of each patient, and we observed a mix of overlapping and differing driver mutations,” says Dr. Johannes Reiter, of Stanford University, one of the lead researchers. “But through computational analyses, we inferred that the driver mutations that were most likely to contribute to cancer development were shared among all metastases in each patient.”
#MathOnco - Book of the month
She Has Her Mother's Laugh:
The Powers, Perversions, and Potential of Heredity
Zimmer: "I feel like heredity is something that is incredibly important in our lives. I sort of wanted to explore the role that heredity has in our lives, and also talk about what science can actually tell us about what heredity really is." In his book, Zimmer convincingly puts forth the complications of heredity; it is an intricate web spun from the threads of genetics and environmental factors. Find a review of the book here.
Most clicked links of September
Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer
Topography of cancer-associated immune cells in human solid tumors
Game Theoretical Model of Cancer Dynamics with Four Cell Phenotypes
Jobs
Do you see something we missed? Reply to this email to send us an idea for next week's issue.
The #MathOnco newsletter is maintained by @jeffreyjizzle. If you were forwarded this email, subscribe for free here to get it delivered every week.