#MathOnco Issue 48: stem cell heterogeneity, adaptive genetic diversity, ALK targeting, network control
This week in
Mathematical Oncology
Jan. 3, 2018 ~ Issue 48
From the editor
Happy New Year!
Will 2019 be the year of mathematical oncology? Most assuredly!
This issue contains models on prostate cancer therapy, stem cell heterogeneity, resistance to ALK targeting, and more.
For my fellow DataViz nerds, I'd encourage you to keep an eye on Semiotic, an interactive data visualization framework which deploys a wide variety of charts that share the same rules for how to display information. Their newest release just added editable annotations.
-Jeffrey West
#MathOnco Publications
The Impact of Intermittent Androgen Suppression Therapy in Prostate Cancer Modeling
Authors: Tin Phan, Kyle Nguyen, Preeti Sharma, Yang Kuang, Yang Kuang
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
Authors: Federico Bocci, Larisa Gearhart-Serna, Marcelo Boareto, Mariana Ribeiro, Eshel Ben-Jacob, Gayathri R. Devi, Herbert Levine, José Nelson Onuchic, and Mohit Kumar Jolly
The dynamics of adaptive genetic diversity during the early stages of clonal evolution
Authors: Jamie R. Blundell, Katja Schwartz, Danielle Francois, Daniel S. Fisher, Gavin Sherlock & Sasha F. Levy
#MathOnco Preprints
Resistance to ALK targeting therapies as a gradual Darwinian adaptation to inhibitor specific selective pressures
Authors: Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Andrew Dhawan, ..., Eric Haura, Jacob Scott, Andriy Marusyk
The mutational landscape of normal human endometrial epithelium
Authors: Luiza Moore, Daniel Leongamornlert, Tim HH Coorens, Mathijs A Sanders, ..., Inigo Martincorena, Kourosh Saeb-Parsy, Peter J Campbell, Michael R. Stratton
Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation: a mathematical and computational examination
Authors: Victor Garcia, Sebastian Bonhoeffer, Feng Fu
A novel structure-based control method for analyzing nonlinear dynamics in biological networks
Authors: Wei-Feng Guo, Shao-Wu Zhang, Tao Zeng, Yan Li, Jianxi Gao, Luonan Chen
#MathOnco News
Seeing Theory
I run across these fantastic examples of data visualization more and more often. This interactive website is part of an upcoming book called Seeing Theory.
"Seeing Theory was created by Daniel Kunin while an undergraduate at Brown University. The goal of this website is to make statistics more accessible through interactive visualizations (designed using Mike Bostock’s JavaScript library D3.js)."
#MathOnco - Book of the month
Cellular Automaton Modeling of Biological Pattern Formation: Characterization, Examples, and Analysis
Andreas Deutsch & Sabine Dormann:
"This text explores the use of cellular automata in modeling pattern formation in biological systems. It describes several mathematical modeling approaches utilizing cellular automata that can be used to study the dynamics of interacting cell systems both in simulation and in practice."
Most clicked links of December
Optimizing adaptive cancer therapy: dynamic programming and evolutionary game theory
A mathematical framework for modelling the metastatic spread of cancer
Jobs
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