#MathOnco Issue 38: get a PhD/PostDoc in MathOnco; universal law of cancer; RNA seq; semi-automatic ODE assembly; the dimensionality curse
This week in
Mathematical Oncology
Oct. 4, 2018 ~ Issue 38
From the editor
Happy Thursday,
With the (relatively) quiet week in math oncology publications, I decided to use the free space to include a few announcements up front here, at the request of a few of our newsletter readers.
Enjoy,
-Jeffrey West
#MathOnco Announcements:
1. Cancer immunotherapy / systems bio postdoc
Fertig Lab: The successful applicant will perform genomics analysis and algorithm development in collaboration with leading computational and clinical investigators in the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Moffitt Cancer Center: Students will have the opportunity to interact with premier investigators in all of these fields and select them for Ph.D. mentoring. Emphasis will be placed on hands-on training and students will have his or her course work tailored to their primary interest. Cancer research is a vitally important and growing field of research. Our graduates will be positioned to lead the way to the future prevention and cure of cancer. Applications due 12/15.
#MathOnco Preprints
Inverse sensitivity analysis of mathematical models avoiding the curse of dimensionality
Authors: Ben Lambert, David Gavaghan, Simon Tavener
The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant rate and for many decades, likely in stem cells
Authors: Aleksey V Belikov
Stationary frequencies and mixing times for neutral drift processes with spatial structure
Authors: Alex McAvoy, Ben Adlam, Benjamin Allen, Martin A. Nowak
Leveraging single cell RNA sequencing experiments to model intra-tumor heterogeneity
Authors: Meghan C Ferrall-Fairbanks, Markus Ball, Eric Padron, Philipp M Altrock
Building mathematical models of biological systems with modelbase, a Python package for semi-automatic ODE assembly and construction of isotope-specific models
Authors: Oliver Ebenhoeh, Marvin van Aalst, Nima Philipp Saadat, Tim Nies, Anna Matuszynska
Intragenomic Conflict over Bet-Hedging
Authors: Jon F Wilkins, Tanmoy Bhattacharya
#MathOnco News
Improving brain-cancer therapies through math modelling
Kat Arney: "Swanson and her colleagues are addressing this challenge by building personalized mathematical models of tumour progression for patients, using data collated from magnetic resonance imaging (MRI) scans rather than from biopsy samples. The team’s models rely on observations that revealed that tumour cells in GBMs exist in one of two states: migration or proliferation — a situation also known as ‘go or grow’."
#MathOnco - Book of the month
She Has Her Mother's Laugh:
The Powers, Perversions, and Potential of Heredity
Zimmer: "I feel like heredity is something that is incredibly important in our lives. I sort of wanted to explore the role that heredity has in our lives, and also talk about what science can actually tell us about what heredity really is." In his book, Zimmer convincingly puts forth the complications of heredity; it is an intricate web spun from the threads of genetics and environmental factors. Find a review of the book here.
#MathOnco - Best of last month
Most clicked links of September
Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer
Topography of cancer-associated immune cells in human solid tumors
Game Theoretical Model of Cancer Dynamics with Four Cell Phenotypes
Do you see something we missed? Click the submit button below to send us an idea for next week's issue.
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