#MathOnco Issue 40: immune selection & evolution; drug perfusion; cellular plasticity; fitness landscapes
This week in
Mathematical Oncology
Oct. 18, 2018 ~ Issue 40
From the editor
Happy Thursday readers!
I want to draw your attention to the fact that all 40 issues of this newsletter are now searchable by title at the mathematical oncology website (here).
You'll find some really intriguing articles below on cellular plasticity modeling and tumor evolution and selection from immune dynamics. If you're like me you might have fallen behind on all these great articles, so I've also included a post on developing good reading habits in the "news" section below.
Enjoy,
-Jeffrey West
PS scroll down to see new job opportunities.
#MathOnco Publications
Evolution of Metastases in Space and Time under Immune Selection
Authors: Mihaela Angelova, Bernhard Mlecnik, Angela Vasaturo, ..., Davide Bedognetti, Marc Van den Eynde, Jerome Galon
Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma
Authors: Yangjin Kim , Hyunji Kang, Gibin Powathil, Hyeongi Kim, Dumitru Trucu, Wanho Lee, Sean Lawler, Mark Chaplain
Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours
Authors: Angela d’Esposito, Paul W. Sweeney, Morium Ali, Magdy Saleh, Rajiv Ramasawmy, Thomas A. Roberts, Giulia Agliardi, Adrien Desjardins, Mark F. Lythgoe, R. Barbara Pedley, Rebecca Shipley & Simon Walker-Samuel
Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
Authors: Andreas Heindl, Adnan Mujahid Khan, Daniel Nava Rodrigues, Katherine Eason, Anguraj Sadanandam, Cecilia Orbegoso, Marco Punta, Andrea Sottoriva, Stefano Lise, Susana Banerjee & Yinyin Yuan
On the deformability of an empirical fitness landscape by microbial evolution
Authors: Djordje Bajić, Jean C. C. Vila, Zachary D. Blount, and Alvaro Sánchez
#MathOnco Preprints
Towards Decoding the Metabolic Plasticity in Cancer: Coupling of Gene Regulation and Metabolic Pathways
Authors: Dongya Jia, Mingyang Lu, Kwang Hwa Jung, Jun Hyoung Park, Linglin Yu, Jose N. Onuchic, Benny Abraham Kaipparettu, Herbert Levine
Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment
Authors: Xuefei Li, Mohit Kumar Jolly, Jason T George, Kenneth J Pienta, Herbert Levine
#MathOnco News
Ten simple rules for developing good reading habits during graduate school and beyond
Marcos Méndez: “Reading is fundamental for keeping updated in the advances of your discipline. However, scholarly literature grows at an increasingly fast pace [6]. Scientists, regardless of the stage in their career, have trouble in navigating an overwhelming amount of relevant literature. This overload can potentially lead to increasingly selective or cursory reading.”
#MathOnco - Book of the month
She Has Her Mother's Laugh:
The Powers, Perversions, and Potential of Heredity
Zimmer: "I feel like heredity is something that is incredibly important in our lives. I sort of wanted to explore the role that heredity has in our lives, and also talk about what science can actually tell us about what heredity really is." In his book, Zimmer convincingly puts forth the complications of heredity; it is an intricate web spun from the threads of genetics and environmental factors. Find a review of the book here.
Most clicked links of September
Mathematical modeling predicts response to chemotherapy and drug combinations in ovarian cancer
Topography of cancer-associated immune cells in human solid tumors
Game Theoretical Model of Cancer Dynamics with Four Cell Phenotypes
Jobs
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