#MathOnco Issue 55: multiscale cell-based models; microenvironmental interactions; state-of-the-art imaging with modeling; statistical mechanics
This week in
Mathematical Oncology
Feb. 21, 2019 ~ Issue 55
From the editor
Hello #MathOnco friends,
A theme of this week's issue is most assuredly spatial cellular interactions. We have several publications on multiscale cell-based models, including a model with microenvironmental interactions, and one neat highlight that combines the power of state-of-the-art imaging with modeling. I've also included a cool approach to combination therapies using statistical mechanics.
The #MathOnco newsletter is taking next week off. See you in March!
-Jeffrey West
#MathOnco Publications
Multiscale Agent-Based and Hybrid Modeling of theTumor Immune Microenvironment
Authors: Kerri-Ann Norton, Chang Gong, Samira Jamalian, Aleksander S. Popel
High-throughput cancer hypothesis testing with an integrated PhysiCell-EMEWS workflow
Authors: Jonathan Ozik, Nicholson Collier, Justin M. Wozniak, Charles Macal, Chase Cockrell, Samuel H. Friedman, Ahmadreza Ghaffarizadeh, Randy Heiland, Gary An and Paul Macklin
All cancer hallmarks lead to diversity
Authors: Alaa Alkhazraji, Mohamed Elgamal, Shi Hui Ang, Velizar Shivarov
Modelling genotypes in their microenvironment to predict single- and multi-cellular behaviour
Authors: Dimitrios Voukantsis Kenneth Kahn Martin Hadley Rowan Wilson Francesca M Buffa
#MathOnco Preprints
Tissue structure accelerates evolution: premalignant sweeps precede neutral expansion
Authors: Jeffrey West, Ryan Schenck, Chandler Gatenbee, Mark Robertson-Tessi, Alexander RA Anderson
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
Authors: Ketevan Chkhaidze, Timon Heide, Benjamin Werner, Marc J Williams, Weini Huang, Giulio Caravagna, Trevor A Graham, Andrea Sottoriva
New combinational therapies for cancer using modern statistical mechanics
Authors: Jorge A. González, M. Acanda, Z. Akhtar, D. Andrews, ..., C. C. Tamayo, D. Valdes, L. Vázquez
#MathOnco News
New 3D imaging technique reveals how pancreatic cancers start
The Francis Crick Institute: "The new method could help researchers to get more information from tissue biopsies and may lead to improved treatments for pancreatic cancers. The technique was developed by scientists at the Francis Crick Institute, and their results are published in Nature." This is an impressive display of the power of combining mathematical modeling with state-of-the-art 3d imaging.
#MathOnco - Book of the month
CSBC/PS-ON Handbook of Mathematical Oncology
A. Anderson, J. Couch, D. Gallahan, N. Moore, K. Swanson, C. Tomlin: The biannual Mathematics of the PS-OC and ICBP workshops were designed to help nurture the developing mathematical oncology community. A direct product of these meetings was a desire to create a shared resource of cancer models and modeling approaches in the form of short and succinct mini-papers with the intention to act as a broader resource that would be enduring for the entire community: a handbook of key methods, concepts, and approaches in Math Oncology.
Most clicked links of January
On the role of tumor heterogeneity for optimal cancer chemotherapy
Paradoxes of tumour complexity: somatic selection, vulnerability by design, or infectious aetiology?
Control Structures of Drug Resistance in Cancer Chemotherapy
Jobs
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