#MathOnco Issue 122: collateral sensitivity, clonal diversity, environmental manipulation, optimal therapy, and patient-specific dynamics.
This week in
Math Oncology
July 9, 2020 ~ Issue 122
From the editor
Hello everyone!
Today's issue of This week in Math Onco includes manuscripts on collateral sensitivity, clonal diversity, environmental manipulation, optimal therapy, and patient-specific dynamics.
There is a new job posting at the bottom of this email, as well (postdoc with David Basanta).
Enjoy,
-Jeffrey West
#MathOnco Publications
Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewing’s sarcoma
Authors: Jessica A. Scarborough, Erin McClure, Peter Anderson, Andrew Dhawan Arda Durmaz, Stephen L. Lessnick, Masahiro Hitomi, Jacob G. Scott
When, why and how tumour clonal diversity predicts survival
Authors: Robert Noble, John T Burley, Cécile Le Sueur, Michael E Hochberg
Optimal scheduling of low-dose metronomic chemotherapy: an in-silico analysis
Authors: Bálint Péceli, Dániel András Drexler Levente Kovács
Tumor Volume Dynamics as an Early Biomarker for Patient-Specific Evolution of Resistance and Progression in Recurrent High-Grade Glioma
Authors: Daniel J. Glazar, G. Daniel Grass, John A. Arrington, Peter A. Forsyth, Natarajan Raghunand, Hsiang-Hsuan Michael Yu, Solmaz Sahebjam, Heiko Enderling
Discrete evolutionary population models: a new approach
Authors: Karima Mokni,Saber Elaydi ,Mohamed CH-Chaoui &Amina Eladdadi
Can Environmental Manipulation Help Suppress Cancer? Non-Linear Competition Among Tumor Cells in Periodically Changing Conditions
Authors: S. G. Babajanyan, Eugene V. Koonin, Kang Hao Cheong
Stem cell lineage survival as a noisy competition for niche access
Authors: Bernat Corominas-Murtra, Colinda L. G. J. Scheele, Kasumi Kishi, Saskia I. J. Ellenbroek, Benjamin D. Simons, Jacco van Rheenen, Edouard Hannezo
Cell-Scale Degradation of Peritumoural Extracellular Matrix Fibre Network and Its Role Within Tissue-Scale Cancer Invasion
Authors: Robyn Shuttleworth, Dumitru Trucu
Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic
Authors: Zaki Hasnain, Tanachat Nilanon, Ming Li, Aaron Mejia, ..., Sriram Yennu, Paul K. Newton, Peter Kuhn, Jorge Nieva
#MathOnco Preprints
Modeling of collaterally sensitive drug cycles, and optimization of the drug effect in the spirit of adaptive therapy
Authors: Nara Yoon, Nikhil P Krishnan, Jacob G Scott
Combination Treatment Optimization Using a Pan-Cancer Pathway Model
Authors: Robin Schmucker, Gabriele Farina, James Faeder, Fabian Froehlich, Ali Sinan Saglam, Tuomas Sandholm
Virtual Seminars
1. Virtual Seminar Series on Modeling Biocomplexity:
Cancer Invasion and Progression Series
Next talk: Marek Kimmel (Rice University, Houston, Texas)
"Site frequency spectra and related statistics, and inference of tumor evolution"
July 15, 2020 at 5:00pm CEST
2. Mathematical and Computational Biology Seminar Series:
Bioinformatics, Computational Biology, General Mathematics
Next talk: Santiago Schnell (University of Michigan)
"Developing models for the accurate measurement of enzyme kinetic parameters"
July 27, 2020 at 11:00am EST
#MathOnco - Book of the month
The Cheating Cell
Athena Aktipis: "When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments."
Jobs
NEW: Postdoc Position - TKI treatments in lung cancer (David Basanta)
Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
Do you see something we missed? Reply to this email to send us an idea for next week's issue.
The #MathOnco newsletter is maintained by Jeffrey West.
If you were forwarded this email, subscribe for free here to get it delivered every week.