#MathOnco Issue 125: cancer eco-evo, superdrivers, dN/dS dynamics, neutral evolution, matrix games, go-or-grow, and more.
This week in
Math Oncology
Aug 6, 2020 ~ Issue 125
From the editor
Dear newsletter readers,
Today's issue includes publications on the cancer eco-evo, superdrivers, dN/dS dynamics, neutral evolution, matrix games, go-or-grow, and more.
I've included a link to the Society for Mathematical Biology annual conference. This year the conference will be held virtually. I plan to attend, and I will look forward seeing & meeting many of you there!
Enjoy,
-Jeffrey West
#MathOnco Publications
Characterizing the ecological and evolutionary dynamics of cancer
Authors: Nastaran Zahir, Ruping Sun, Daniel Gallahan, Robert A. Gatenby & Christina Curtis
A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma
Authors: Boris Aguilar, David L Gibbs, David J Reiss, Mark McConnell, Samuel A Danziger, Andrew Dervan, Matthew Trotter, Douglas Bassett, Robert Hershberg, Alexander V Ratushny, Ilya Shmulevich
Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells
Authors: Helen K. Alexander, R. Craig MacLean
Integrating evolutionary dynamics into cancer therapy
Authors: Robert A. Gatenby, Joel S. Brown
Effect of delays in the 2-week-wait cancer referral pathway during the COVID-19 pandemic on cancer survival in the UK: a modelling study
Authors: Amit Sud, Bethany Torr, Michael E Jones, John Broggio, ..., Ethna McFerran, Mark Lawler, Richard Houlston, Clare Turnbull
Clonal evolution driven by superdriver mutations
Authors: Patrick Grossmann, Simona Cristea, Niko Beerenwinkel
Pan-cancer image-based detection of clinically actionable genetic alterations
Authors: Jakob Nikolas Kather, Lara R. Heij, Heike I. Grabsch, Chiara Loeffler, ..., Dirk Jäger, Christian Trautwein, Alexander T. Pearson, Tom Luedde
Optimization of Dose Fractionation for Radiotherapy of a Solid Tumor with Account of Oxygen Effect and Proliferative Heterogeneity
Authors: Maxim Kuznetsov, Andrey Kolobov
Intrinsic Radiosensitivity Is Not the Determining Factor in Treatment Response Differences between HPV Negative and HPV Positive Head and Neck Cancers
Authors: Paul Reid, Alexander H. Staudacher, Loredana G. Marcu, Ian Olver, Leyla Moghaddasi, Michael P. Brown, Yanrui Li, Eva Bezak
#MathOnco Preprints
dN/dS dynamics quantify tumour immunogenicity and predict response to immunotherapy
Authors: Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Trevor A Graham, Andrea Sottoriva
Signatures of neutral evolution in exponentially growing tumors: a theoretical perspective
Authors: Hwai-Ray Tung, Rick Durrett
DyPy: A Python Library for Simulating Matrix-Form Games
Authors: Anjalika Nande, Andrew Ferdowsian, Eric Lubin, Erez Yoeli, Martin Nowak
Mathematical modeling of glioma invasion: acid- and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy
Authors: Martina Conte, Christina Surulescu
Invasion fronts and adaptive dynamics in a model for the growth of cell populations with heterogeneous mobility
Authors: Tommaso Lorenzi, Benoît Perthame, Xinran Ruan
Virtual Seminars
1. Moffitt's Integrated Mathematical Oncology Dept. Series
Mathematical Oncology Series
Next talk: Dr. Elsa Hansen (Pennsylvania State University)
"Ecological considerations of trial design to test competitive suppression of resistance"
Aug. 6, 2020 at 12:00pm EST
2. SMB 2020 Annual Meeting
Society for Mathematical Biology
August 17 through 20 from 8:00am - 5:00pm EST
Plenary Speakers:
Carl Bergstrom
Shayn Peirce-Cottler
Keynote Speakers:
Alicia Prieto Langarica
David Ho
Robert Insall
Priyanga Amarasekare
Andrea Bild
Adam Martin
Sue Ann Campbell
Deirdre Hollingsworth
#MathOnco - Book of the month
The Cheating Cell
Athena Aktipis: "When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments."
Jobs
NEW: Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Postdoc Position - TKI treatments in lung cancer (David Basanta)
Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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