#MathOnco Issue 126: eco-onccology, collective motion, reproducibility, multi-scale models, and more.
This week in
Math Oncology
Aug 13, 2020 ~ Issue 126
From the editor
Dear newsletter readers,
Today's issue includes publications on eco-oncology, collective motion, reproducibility, multi-scale models, and more.
I've included a link to the (virtual) Society for Mathematical Biology annual conference, again this week. Feel free to reach out if you're attending -- I'd love to meet or catch up with you!
Enjoy,
-Jeffrey West
PS. For something totally different this week, I also included a link to a neat documentary on my favorite scientist -- Claude Shannon.
#MathOnco Publications
Universal scaling laws rule explosive growth in human cancers
Authors: Víctor M. Pérez-García, Gabriel F. Calvo, Jesús J. Bosque, Odelaisy León-Triana, ..., Antonio F. Honguero Martínez, Germán A. Jiménez Londoño, Estanislao Arana, Ana M. García Vicente
Eco‐oncology: Applying ecological principles to understand and manage cancer
Authors: Brent A. Reynolds, Monika W. Oli, Madan K. Oli
Insights From the Ecology of Information to Cancer Control
Authors: Christopher J. Whelan, Stanislav S. Avdieiev, Robert A. Gatenby
Modelling collective cell motion: are on- and off-lattice models equivalent?
Authors: Josué Manik Nava-Sedeño, Anja Voß-Böhme, Haralampos Hatzikirou, Andreas Deutsch and Fernando Peruani
What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
Authors: Anna K. Miller, Joel S. Brown, David Basanta, Nancy Huntly
Agent-Based Modeling and Simulation in Mathematics and Biology Education
Authors: Erin N. Bodine, Robert M. Panoff, Eberhard O. Voit, Anton E. Weisstein
Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis
Authors: Kritika Saxena, Mohit Kumar Jolly, Kuppusamy Balamurugan
The Evolution of Metapopulation Dynamics and the Number of Stem Cells in Intestinal Crypts and Other Tissue Structures in Multicellular Bodies
Authors: David Birtwell, Georg Luebeck, Carlo C. Maley
#MathOnco Preprints
Transition Therapy: Tackling the Ecology of Tumour Phenotypic Plasticity
Authors: Guim Aguade, Stuart Kauffman, Ricard Sole
Multi-scale modeling of macrophage – T cell interactions within the tumor microenvironment and impacts of macrophage-based immunotherapies
Authors: Colin G. Cess, Stacey D. Finley
Reproducibility in systems biology modelling
Authors: Krishna Tiwari, Sarubini Kananathan, Matthew G Roberts, Johannes P Meyer, ...Tung V N Nguyen, Mihai Glont, Henning Hermjakob, Rahuman S Malik Sheriff
Special Issue:
"Mathematical Models of Cellular Immunotherapies in Cancer"
Announcement: Cellular therapies in cancer constitute an emerging field including many different therapeutic strategies. Many of these strategies typically work by collecting a specific set of cells from patients, modifying them to produce some kind of attack on a patient's cancer cells, and then reinjecting them into the patient. Some examples are tumor-infiltrating lymphocytes, engineered T-cell receptor, chimeric antigen receptor (CAR)-T cells, cytotoxic T lymphocytes, natural killer cells, and mesenchymal stem cells.
In this Special Issue, we plan to address cellular therapies from a mathematical and computational modeling perspective. Mathematical modeling has the potential to help in finding optimal administration protocols, provide a deeper understanding of the mechanisms and dynamics, help in the design of new clinical trials, and more. Despite the immense potential of these treatments, applied mathematicians and computational modelers have started to study these processes only very recently.
With this Special Issue we plan to stimulate further much needed research in the field and provide a way for disseminating state-of-the-art research on mathematical models of cell therapies in cancer.
You are kindly invited to contribute to this special issue. The journal Cancers has an impact factor of 6.126 and ranks 37/244 in the JCR category “Oncology”. More information can be found on the website
Guest Editors:
Víctor Pérez-García, Lisette de Pillis, Philipp Altrock, Russell Rockne
The Bit Player
Claude Shannon documentary
In 1948, Claude Shannon introduced the notion of a "bit", laying the foundation for the Information Age. His ideas power our modern life, influencing computing, genetics, neuroscience and AI. Mixing contemporary interviews, archival film, animation, and dialogue from interviews with Shannon, The Bit Player tells the story of an overlooked genius with unwavering curiousity.
Virtual Seminars
1. Moffitt's Integrated Mathematical Oncology Dept. Series
Mathematical Oncology Series
Next talk: Dr. Russell Rockne (City of Hope)
"Targeted radioimmunotherapy and CAR T-cell combination therapy for multiple myeloma: from bench to math to bedside and back again"
Aug. 13, 2020 at 12:00pm EST
2. SMB 2020 Annual Meeting
Society for Mathematical Biology
August 17 through 20 from 8:00am - 5:00pm EST
Plenary Speakers:
Carl Bergstrom
Shayn Peirce-Cottler
Keynote Speakers:
Alicia Prieto Langarica
David Ho
Robert Insall
Priyanga Amarasekare
Andrea Bild
Adam Martin
Sue Ann Campbell
Deirdre Hollingsworth
#MathOnco - Book of the month
The Cheating Cell
Athena Aktipis: "When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments."
Jobs
Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Postdoc Position - TKI treatments in lung cancer (David Basanta)
Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
Do you see something we missed? Reply to this email to send us an idea for next week's issue.
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