#MathOnco Issue 130: tumor architecture, spatial structure, biomarkers, hypoxia/acidity, ecological principles applied to pesticides.
This week in
Math Oncology
Sept 10, 2020 ~ Issue 130
From the editor
Dear readers,
Today's issue includes a wide variety of topics: tumor architecture, spatial structure, biomarkers, hypoxia/acidity, and I've also included an interesting overview of ecological principles applied to pesticides.
Enjoy,
-Jeffrey West
#MathOnco Publications
Mechanics of a multilayer epithelium instruct tumour architecture and function
Authors: Vincent F. Fiore, Matej Krajnc, Felipe Garcia Quiroz, John Levorse, H. Amalia Pasolli, Stanislav Y. Shvartsman, Elaine Fuchs
Mutant Evolution in Spatially Structured and Fragmented Expanding Populations
Authors: Dominik Wodarz, Natalia L. Komarova
NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype
Authors: Ayalur Raghu Subbalakshmi, Deepali Kundnani, Kuheli Biswas, Anandamohan Ghosh, Samir M. Hanash, Satyendra C. Tripathi, Mohit Kumar Jolly
Genomic copy number predicts esophageal cancer years before transformation
Authors: Sarah Killcoyne, Eleanor Gregson, David C. Wedge, Dan J. Woodcock, ..., Wladyslaw Januszewicz, Aikaterini Varanou Jenkins, Moritz Gerstung, Rebecca C. Fitzgerald
Pesticide dosing must be guided by ecological principles
Authors: Théotime Colin, Coline Monchanin, Mathieu Lihoreau, Andrew B. Barron
#MathOnco Preprints
A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer
Authors: Giada Fiandaca, Marcello Delitala, Tommaso Lorenzi
Selection of metastasis competent subclones in the tumour interior: TRACERx renal
Authors: Yue Zhao, Xiao Fu, Jose Lopez, Andrew Rowan, ..., Paul Bates, Charles Swanton, Samra Turajlic, Kevin Litchfield
Mutational landscapes of normal breast during age and pregnancy determine cancer risk
Authors: Biancastella Cereser, Neha Tabassum, Lisa Del Bel Belluz, Angela Yiu, View ORCID ProfileSladjana Zagorac, Cristian Miere, Benjamin Werner, Nina Moderau, Alicia Rose Jeffries-Jones, Justin Stebbing
Limited evidence of tumour mutational burden as a biomarker of response to immunotherapy
Authors: Carino Gurjao, Dina Tsukrov, Maxim Imakaev, Lovelace J. Luquette, Leonid A. Mirny
Towards integration of 64Cu-DOTA-Trasztusumab PET-CT and MRI with mathematical modeling to predict response to neoadjuvant therapy in HER2+ breast cancer
Authors: Angela M. Jarrett, David A. Hormuth II, Vikram Adhikarla, Prativa Sahoo, Daniel Abler, Lusine Tumyan, Daniel Schmolze, Joanne Mortimer, Russell C. Rockne, Thomas E. Yankeelov
Special Issue:
Latest Developments in Mathematical Oncology and Cancer Systems Biology
Announcement: Here, we invite investigators in the interdisciplinary field of mathematical oncology and cancer systems biology to contribute their latest research articles and/or review articles and perspectives on applying the different kinds of computational, mathematical, and statistical tools and techniques to applicable biological or clinical data to train such models to better elucidate the dynamics of tumor progression, to identify novel therapeutic schemas or targets, and to design more effective therapies.
Guest Editors:
Mohit Kumar Jolly, Heiko Enderling
Special Issue:
"Mathematical Models of Cellular Immunotherapies in Cancer"
Announcement: In this Special Issue, we plan to address cellular therapies from a mathematical and computational modeling perspective. Mathematical modeling has the potential to help in finding optimal administration protocols, provide a deeper understanding of the mechanisms and dynamics, help in the design of new clinical trials, and more. Despite the immense potential of these treatments, applied mathematicians and computational modelers have started to study these processes only very recently.
Guest Editors:
Víctor Pérez-García, Lisette de Pillis, Philipp Altrock, Russell Rockne
#MathOnco Virtual Seminars
Moffitt's Integrated Mathematical Oncology Dept. Series
Mathematical Oncology Series
1. Dr. Kathleen (Kit) Curtius
"Computational modeling of cancer evolution to optimize screening and surveillance"
Sep 10, 2020 12:00pm US Eastern
2. Dr. Laura Heiser
"The molecular control of cancer-associated phenotypic states in mammary epithelial cells"
Sep 24, 2020 12:00pm US Eastern
#MathOnco - Book of the month
The Cheating Cell
Athena Aktipis: "When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments."
Jobs
NEW: Principal Scientist – Oncology PK/PD Modelling (Boehringer Ingelheim)
NEW: Treating glioblastoma with immunotherapies (Morgan Craig)
Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Postdoc Position - TKI treatments in lung cancer (David Basanta)
Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
Do you see something we missed? Reply to this email to send us an idea for next week's issue.
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