#MathOnco Issue 131: evolutionary dynamics of neoantigens, colorectal cancer initiation, cancer/wound healing hallmarks, resistance & recurrence
This week in
Math Oncology
Sept 17, 2020 ~ Issue 131
From the editor
Dear readers,
Today's issue includes evolutionary dynamics of neoantigens, colorectal cancer initiation, cancer/wound healing hallmarks, resistance & recurrence and more. I've also included a link to Samir Amin's absolutely excellent resource for anyone thinking about applying for a K99/R00 grant.
Enjoy,
-Jeffrey West
#MathOnco Publications
Mathematical model of colorectal cancer initiation
Authors: Chay Paterson, Hans Clevers, Ivana Bozic
Evolutionary dynamics of neoantigens in growing tumors
Authors: Eszter Lakatos, Marc J. Williams, Ryan O. Schenck, William C. H. Cross, ..., Chris P. Barnes, Alexander R. A. Anderson, Andrea Sottoriva, Trevor A. Graham
Modeling How Heterogeneity in Cell Cycle Length Affects Cancer Cell Growth Dynamics in Response to Treatment
Authors: Eleftheria Tzamali, Georgios Tzedakis, Vangelis Sakkalis
The hallmarks of cancer are also the hallmarks of wound healing
Authors: Lucy MacCarthy-Morrogh, Paul Martin
Computational and systems biology of cancer
Authors: David Dingli
Modeling Resistance and Recurrence Patterns of Combined Targeted- Chemoradiotherapy Predicts Benefit of Shorter Induction Period
Authors: David M. McClatchy, Henning Willers, Aaron N. Hata, Zofia Piotrowska, Lecia V. Sequist, Harald Paganetti, Clemens Grassberger
Pluripotent Stem Cell Modeling of Anticancer Therapy–Induced Cardiotoxicity
Authors: Davi M. Lyra-Leite, Paul W. Burridge
#MathOnco Preprints
CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Authors: Odelaisy León-Triana, Soukaina Sabir, Gabriel F. Calvo, Juan Belmonte-Beitia, Salvador Chulián, Álvaro Martínez-Rubio, María Rosa, Antonio Pérez-Martínez, Manuel Ramirez-Orellana, Víctor Pérez-García
Writing a K99/R00 Grant · SBAmin.com
Samir Amin: "K99/R00: Pathway to Independence Award is a NIH funded grant mechanism for a postdoctoral fellow aiming to establish an independent research career following structured postdoctoral training. I have recently - June, 2020 cycle - applied K99/R00 grant. I wrote my experience as a guide that I hope prospective applicants would find resourceful. You can view the guide at https://k99.sbamin.com"
Special Issue:
Latest Developments in Mathematical Oncology and Cancer Systems Biology
Guest Editors: M. Kumar Jolly, H. Enderling
Announcement: Here, we invite investigators in the interdisciplinary field of mathematical oncology and cancer systems biology to contribute their latest research articles and/or review articles and perspectives on applying the different kinds of computational, mathematical, and statistical tools and techniques to applicable biological or clinical data to train such models to better elucidate the dynamics of tumor progression, to identify novel therapeutic schemas or targets, and to design more effective therapies.
Special Issue:
"Mathematical Models of Cellular Immunotherapies in Cancer"
Guest Editors: V. Pérez-García, L. de Pillis, P. Altrock, R. Rockne
Announcement: In this Special Issue, we plan to address cellular therapies from a mathematical and computational modeling perspective. Mathematical modeling has the potential to help in finding optimal administration protocols, provide a deeper understanding of the mechanisms and dynamics, help in the design of new clinical trials, and more. Despite the immense potential of these treatments, applied mathematicians and computational modelers have started to study these processes only very recently.
#MathOnco Virtual Seminars
ISoP MCS SIG Webinar Series
Next talk: Dr. Trachette Jackson, University of Michigan
"Mathematical Models of Targeted Cancer Therapeutics"
Register here.
Sep 24, 2020 11:00am US Eastern
Moffitt's Integrated Mathematical Oncology Dept. Series
Mathematical Oncology Series
Next talk: Dr. Laura Heiser
"The molecular control of cancer-associated phenotypic states in mammary epithelial cells"
Sep 24, 2020 12:00pm US Eastern
#MathOnco - Book of the month
The Cheating Cell
Athena Aktipis: "When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments."
Jobs
NEW: Principal Scientist – Oncology PK/PD Modelling (Boehringer Ingelheim)
NEW: Treating glioblastoma with immunotherapies (Morgan Craig)
Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Postdoc Position - TKI treatments in lung cancer (David Basanta)
Research Associate, Postdoc, and Research Faculty positions – Mathematical Oncology (Russ Rockne)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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