#MathOnco Issue 56: immune-mediated mets; quasi birth-death; multi-region sequencing; epidermis clonality
This week in
Mathematical Oncology
March 7, 2019 ~ Issue 56
From the editor
Hello #MathOnco friends,
While I took the week off, you all most certainly did not! This week's issue is a data dump of the past few weeks flurry of exciting papers. Also, I've recently picked up DeGregori's Adaptive Oncogenesis again, and I've included a link below. It's intriguing and I commend it to you.
This newsletter has continuously expanded over the past few months (thank you, dear readers!). With that, I wanted to note all our resources here at the top, in case you're new, or you've missed some details:
Searchable: newsletter archive at mathematical-oncology.org
Submit: reply to this email with a link to your recent work
Statistics: read the purpose and history behind this newsletter
Enjoy,
-Jeffrey West
#MathOnco Publications
Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer
Authors: Artem Kaznatcheev, Jeffrey Peacock, David Basanta, Andriy Marusyk & Jacob G. Scott
Recasting the Cancer Stem Cell Hypothesis: Unification Using a Continuum Model of Microenvironmental Forces
Authors: Jacob G. Scott, Andrew Dhawan, Anita Hjelmeland, Justin Lathia, Anastasia Chumakova, Masahiro Hitomi, Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson
Blackboard to Bedside: A Mathematical Modeling Bottom-Up Approach Toward Personalized Cancer Treatments
Authors: Sara Hamis, Gibin G. Powathil1, Mark A.J. Chaplain
#MathOnco Preprints
Measuring single cell divisions in human cancers from multi-region sequencing data
Authors: Benjamin Werner, Jack Case, Marc J Williams, Kate Chkhaidze, Daniel Temko, Javier Fernandez-Mateos, George D Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
A spatial cell culture model for predicting chemotherapy dosing strategies
Authors: Shu Zhu, Dhruba Deb, Tal Danino
A Mathematical Model for the Immune-Mediated Theory of Metastasis
Authors: Adam Rhodes, Thomas Hillen
A Quasi Birth-and-Death Model For Tumor Recurrence
Authors: Leonardo M. Santana, Gyan Bhanot, Shridar Ganesan
Context-dependent selection as the keystone in somatic evolution of cancer
Authors: Milind Watve, B Vibishan
Clonal Architecture of the Epidermis: Homeostasis Limits Keratinocyte Evolution
Authors: Ryan O Schenck, Eunjung Kim, Rafael Bravo, Jeffrey West, Simon Leedham, Darryl Shibata, Alexander R.A. Anderson
#MathOnco News
News & Views: Resistance Games
Kateřina Staňková: "A game theory study supported by in vitro experimental data shows that drug treatment of non-small-cell lung cancer cells causes the cells to switch between evolutionary games they play among each other. Moreover, the work calls into question standard assumptions on the fitness costs of drug resistance to cancer cells."
#MathOnco - Book of the month
Adaptive Oncogenesis:
A New Understanding of How Cancer Evolves Inside Us
James DeGregori: This book, "corrects the fundamental attribution error that has focused cancer research on malignant cells and their genes. Adaptive oncogenesis, or ‘EcoOncogenesis,’ shows that the ecosystems surrounding cells are equally important, responsible for creating selection forces that speed or slow the evolution of cancer. "
Most clicked links of February
A Review of Cell-Based Computational Modeling in Cancer Biology
Nonlinear adaptive control of competitive release and chemotherapeutic resistance
New combinational therapies for cancer using modern statistical mechanics
Jobs
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