#MathOnco Issue 57: evolutionary complexity, phenotypic tradeoffs, immune-tumor interactions
This week in
Mathematical Oncology
March 14, 2019 ~ Issue 57
From the editor
Hello #MathOnco friends,
I probably say this every week, but I am extra excited at the contents of this week's newsletter! I always love seeing articles on evolutionary game theory in cancer (my personal favorite). There's also some publications on evolutionary complexity, phenotypic tradeoffs, immune-tumor interactions, all very exciting!
Enjoy,
-Jeffrey West
#MathOnco Publications
The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer
Authors: Jill A. Gallaher, Joel S. Brown & Alexander R. A. Anderson
The Immune Checkpoint Kick Start: Optimization of Neoadjuvant Combination Therapy Using Game Theory
Authors: Jeffrey West, Mark Robertson-Tessi, Kimberly Luddy, Derek S. Park, Drew F.K. Williamson, Cathal Harmon, Hung T. Khong, Joel Brown, Alexander R.A. Anderson
Computational Complexity as an Ultimate Constraint on Evolution
Authors: Artem Kaznatcheev
#MathOnco Preprints
Learning-accelerated Discovery of Immune-Tumour Interactions
Authors: Jonathan Ozik, Nicholson Collier, Randy Heiland, Paul Macklin
The invasion of de-differentiating cancer cells into hierarchical tissues
Authors: Da Zhou, Yue Luo, David Dingli, Arne Traulsen
Exploiting evolutionary herding to control drug resistance in cancer
Authors: Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D. Cresswell, ..., Carlo C. Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva
The evolutionary dynamics and fitness landscape of clonal haematopoiesis
Authors: Caroline J. Watson, Alana Papula, Yeuk P. G. Poon, Wing H. Wong, Andrew L. Young, Todd E. Druley, Daniel S. Fisher, Jamie R. Blundell
Measuring single cell divisions in human cancers from multi-region sequencing data
Authors: Benjamin Werner, Jack Case, Marc J Williams, Kate Chkhaidze, ..., Ian Tomlinson, Chris P Barnes, Trevor A Graham, Andrea Sottoriva
#MathOnco News
The road to measuring evolutionary games in cancer
Jacob Scott: "In addition to being ABLE to measure a game, we wanted to start with a situation which we thought would have a decent chance of also being interesting. We had just come off a project studying the changes in drug sensitivity over time of ALK mutated non-small cell lung cancer, and so had evolved TKI-resistant lung cancer cells lying around. We hypothesized (as most were at the time) that there would be a *cost* to the resistance, which we might be able to take advantage of in the form of a measurable *trade-off*. A quick and dirty first experiment that Jeff ran gave us some hope that this might be true."
#MathOnco - Book of the month
Adaptive Oncogenesis:
A New Understanding of How Cancer Evolves Inside Us
James DeGregori: This book, "corrects the fundamental attribution error that has focused cancer research on malignant cells and their genes. Adaptive oncogenesis, or ‘EcoOncogenesis,’ shows that the ecosystems surrounding cells are equally important, responsible for creating selection forces that speed or slow the evolution of cancer. "
Most clicked links of February
A Review of Cell-Based Computational Modeling in Cancer Biology
Nonlinear adaptive control of competitive release and chemotherapeutic resistance
New combinational therapies for cancer using modern statistical mechanics
Jobs
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