#MathOnco Issue 74: evolutionary selection, therapy, prediction and more!
This week in
Math Oncology
July 18, 2019 ~ Issue 74
From the editor
#MathOnco friends,
If there were a theme to this week's newsletter it might be evolution. I've lumped some of the most exciting preprints and publications on evolutionary selection, therapy, and prediction in cancer below. Interestingly, a few studies on drug dose response dropped this week as well, making waves with a lack of reproducibility. Scroll down to read more,
-Jeffrey West
PS. Next week I'll be at the Society of Math Bio meeting in Montreal - if you're there please come say hi, I would love to meet you!
#MathOnco Publications
Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer
Authors: Arturo Álvarez-Arenas, Ana Podolski-Renic, Juan Belmonte-Beitia, Milica Pesic & Gabriel F. Calvo
A review of mathematical models for tumor dynamics and treatment resistance evolution of solid tumors
Authors: Anyue Yin, Dirk Jan A.R. Moes, Johan G.C. van Hasselt, Jesse J Swen, Henk‐Jan Guchelaar
Estimating the predictability of cancer evolution
Authors: Sayed-Rzgar Hosseini Ramon Diaz-Uriarte Florian Markowetz Niko Beerenwinkel
Integrating Mathematical Modeling into the Roadmap for Personalized Adaptive Radiation Therapy
Authors: Heiko Enderling, Juan Carlos López Alfonso, Eduardo Moros, Jimmy J. Caudell, Louis B. Harrison
#MathOnco Preprints
Representing fitness landscapes by valued constraints to understand the complexity of local search
Authors: Artem Kaznatcheev, David A. Cohen, Peter G. Jeavons
A Survey and Systematic Assessment of Computational Methods for Drug Response Prediction
Authors: Jinyu Chen, Louxin Zhang
Non-genetic intra-tumor heterogeneity is a major predictor of phenotypic heterogeneity and ongoing evolutionary dynamics in lung tumors
Authors: Anchal Sharma, Elise Merritt, Angelique Cruz, Chuan Jiang, Halle Sarkodie, Zhan Zhou, Jyoti Malhotra, Gregory M Riedlinger, Subhajyoti De
Evolutionary dynamics with stochastic game transitions
Authors: Qi Su, Alex McAvoy, Long Wang, Martin A. Nowak
A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT)
Authors: Wen Jia, Abhijeet Deshmukh, Sendurai A. Mani, Mohit Kumar Jolly, Herbert Levine
The Research Ecosystem: Where does Mathematical Oncology Fit
Ryan Schenck: "The output of this research ecosystem is really what impacts the patients and the community. It’s the hope that what we do means that patients, and we, can spend a few more years with our parents, grandchildren, and devastatingly, children at times. (...) We need to have ways to treat patients smarter and make sure we are utilizing proper dosages. But where does mathematical biology fit into any of this ecosystem?"
Potential Causes of Irreproducibility Revealed
Abby Olena: "Five independent groups got different results in a drug-response experiment, despite sharing protocols, reagents, and cell lines. The researchers identify technical variables that could be to blame."
#MathOnco - Book of the month
When Breath Becomes Air
We sometimes find ourselves hiding in the comfort and safety of the details of math models, neglecting to meditate on the real-world implications of the math. This book is for us.
"At the age of thirty-six, on the verge of completing a decade’s worth of training as a neurosurgeon, Paul Kalanithi was diagnosed with stage IV lung cancer. One day he was a doctor treating the dying, and the next he was a patient struggling to live."
Most clicked links of June
Mathematical Modelling of Phenotypic Selection Within Solid Tumours
Numerical optimal control of a size-structured PDE model for metastatic cancer treatment
Learning-accelerated Discovery of Immune-Tumour Interactions
Growth dynamics in naturally progressing chronic lymphocytic leukaemia
Jobs
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