#MathOnco Issue 85: invasive cancer; division rates; subclonal mutation frequency; evolutionary trajectories; CAR T-cell
This week in
Math Oncology
Oct. 3, 2019 ~ Issue 85
From the editor
#MathOnco friends,
Of note in this issue, there is an interesting mini-review called "Treating Cancer as an Invasive Species," where the authors coin the term "heterogeneity engineering." I very much appreciate the new term which encapsulates a lot of the interest in evolutionary-inspired therapies that are prevalent in math oncology.
In case you missed it, scroll down to the bottom to see the best of the September links!
Please enjoy!
-Jeffrey West
#MathOnco Publications
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence
Authors: Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., ..., Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, Bert Vogelstein
Treating Cancer as an Invasive Species
Authors: Javad Noorbakhsh, Zi-Ming Zhao, James C Russell and Jeffrey H Chuang
On measuring selection in cancer from subclonal mutation frequencies
Authors: Ivana Bozic, Chay Paterson, Bartlomiej Waclaw
#MathOnco Preprints
TrackSig: reconstructing evolutionary trajectories of mutations in cancer
Authors: Yulia Rubanova, Ruian Shi, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, Quaid Morris, PCAWG Evolution and Heterogeneity Working Group, PCAWG network
Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics
Authors: Atish Agarwala, Daniel S. Fisher
Comparative Anatomical Limits of CART-Cell Delivery to Tumours in Mice and Men
Authors: Liam V Brown, Eamonn A Gaffney, Ann Ager, Jonathan Wagg, Mark C Coles
Improving personalized prediction of cancer prognoses with clonal evolution models
Authors: Yifeng Tao, Ashok Rajaraman, Xiaoyue Cui, Ziyi Cui, Jesse Eaton, Hannah Kim, Jian Ma, Russell Schwartz
Haplotype-based inference of the distribution of fitness effects
Authors: Diego Ortega-Del Vecchyo, Kirk E. Lohmueller, John Novembre
Short-Range Migration Can Alter Evolutionary Dynamics in Solid Tumors
Authors: Youness Azimzade, Abbas Ali Saberi
R: Practical ggplot2
Claus O. Wilke: "The R package ggplot2 provides a powerful and flexible approach to data visualization, and it is suitable both for rapid exploration of different visualization approaches and for producing carefully crafted publication-quality figures. However, getting ggplot2 to make figures that look exactly the way you want them to can sometimes be challenging, and beginners and experts alike can get confused by themes, scales, coords, guides, or facets. This repository houses a set of step-by-step examples demonstrating how to get the most out of ggplot2, including how to choose and customize scales, how to theme plots, and when and how to use extension packages."
#MathOnco - Book of the month
The Maths of Life and Death
Kit Yates: "In this eye-opening and extraordinary book, Yates explores the true stories of life-changing events in which the application - or misapplication - of mathematics has played a critical role: patients crippled by faulty genes and entrepreneurs bankrupted by faulty algorithms; innocent victims of miscarriages of justice and the unwitting victims of software glitches. We follow stories of investors who have lost fortunes and parents who have lost children, all because of mathematical misunderstandings."
Most clicked links of September
Systems biology approaches to measure and model phenotypic heterogeneity in cancer
Modeling genetic heterogeneity of drug response and resistance in cancer
A Monte Carlo method to estimate cell population heterogeneity
Jobs
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Data-driven modeling of breast cancer metastasis - Postdoc (Paul Macklin)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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