This week in MathOnco 156

Extinction, multi-scale, T-cell movement, co-culture competition, mechanical stress in tumors.

Jeffrey West

Apr 01, 2021

`Apr. 1, 2021 >``jeffrey.west@moffitt.org`

`From the editor:`

Summary of contents:

Stochastic extinction in CAR-T therapy
Breast cancer cell line competition
A review on the treatment of metastases
Multi-scale models of tumor oxygenation
A nice preprint on T-cells, along with a neat movie of T-cells in action on Twitter.

Enjoy, -Jeffrey West

The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapy
Gregory J. Kimmel, Frederick L. Locke, Philipp M. Altrock
Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture
Marisbel Rodriguez Messan, Mehdi Damaghi, Audrey Freischel, Yan Miao, Joel Brown, Robert Gillies, Dorothy Wallace
Breast tumours maintain a reservoir of subclonal diversity during expansion
Darlan C. Minussi, Michael D. Nicholson, Hanghui Ye, Alexander Davis, …, Funda Meric-Bernstam, Peter Van Loo, Franziska Michor, Nicholas E. Navin
Emerging strategies for treating metastasis
Mark Esposito, Shridar Ganesan, Yibin Kang
A novel 3D atomistic-continuum cancer invasion model: in silico simulations of an in vitro organotypic invasion assay
Linnea C. Franssen, Nikolaos Sfakianakis, Mark A.J. Chaplain

Mechanical influences on in silico tumor evolution
Jakob Rosenbauer, Marco Berghoff, James A. Glazier, Alexander Schug
A Multiscale Immuno-Oncology on-Chip System (MIOCS) establishes that collective T cell behaviors govern tumor regression
Gustave Ronteix, Shreyansh Jain, Christelle Angely, Marine Cazaux, Roxana Khazen, Philippe Bousso, Charles N. Baroud
Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination
Kamran Kaveh, Feng Fu
Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations
Jessica L. Kingsley, James R. Costello, Natarajan Raghunand, Katarzyna A. Rejniak
Evaluating glioma growth predictions as a forward ranking problem
Karin A. van Garderen, Sebastian R. van der Voort, Maarten M.J. Wijnenga, Fatih Incekara, Georgios Kapsas, Renske Gahrmann, Ahmad Alafandi, Marion Smits, Stefan Klein

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