This week in MathOnco 156

Extinction, multi-scale, T-cell movement, co-culture competition, mechanical stress in tumors.

“This week in Mathematical Oncology” — Newsletter

Apr. 1, 2021
>jeffrey.west@moffitt.org

From the editor:


Summary of contents:

• Stochastic extinction in CAR-T therapy

• Breast cancer cell line competition

• A review on the treatment of metastases

• Multi-scale models of tumor oxygenation

• A nice preprint on T-cells, along with a neat movie of T-cells in action on Twitter.

Enjoy,
-Jeffrey West

1. The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapy
   Gregory J. Kimmel, Frederick L. Locke, Philipp M. Altrock

2. Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture
   Marisbel Rodriguez Messan, Mehdi Damaghi, Audrey Freischel, Yan Miao, Joel Brown, Robert Gillies, Dorothy Wallace

3. Breast tumours maintain a reservoir of subclonal diversity during expansion
   Darlan C. Minussi, Michael D. Nicholson, Hanghui Ye, Alexander Davis, …, Funda Meric-Bernstam, Peter Van Loo, Franziska Michor, Nicholas E. Navin

4. Emerging strategies for treating metastasis
   Mark Esposito, Shridar Ganesan, Yibin Kang

5. A novel 3D atomistic-continuum cancer invasion model: in silico simulations of an in vitro organotypic invasion assay
   Linnea C. Franssen, Nikolaos Sfakianakis, Mark A.J. Chaplain

1. Mechanical influences on in silico tumor evolution
   Jakob Rosenbauer, Marco Berghoff, James A. Glazier, Alexander Schug

2. A Multiscale Immuno-Oncology on-Chip System (MIOCS) establishes that collective T cell behaviors govern tumor regression
   Gustave Ronteix, Shreyansh Jain, Christelle Angely, Marine Cazaux, Roxana Khazen, Philippe Bousso, Charles N. Baroud

3. Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination
   Kamran Kaveh, Feng Fu

4. Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations
   Jessica L. Kingsley, James R. Costello, Natarajan Raghunand, Katarzyna A. Rejniak

5. Evaluating glioma growth predictions as a forward ranking problem
   Karin A. van Garderen, Sebastian R. van der Voort, Maarten M.J. Wijnenga, Fatih Incekara, Georgios Kapsas, Renske Gahrmann, Ahmad Alafandi, Marion Smits, Stefan Klein

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• Networks in Cancer: From Symmetry Breaking to Targeted Therapy
  Guest Editor: Cristian Axenie, Roman Bauer, María Rodríguez Martínez

• Understanding the Evolutionary Dynamics and Ecology of Cancer in Treatment Resistance
  Guest Editor: David Basanta

• Mathematical Models of Cellular Immunotherapies in Cancer
  Guest Editors: V. Pérez-García, L. de Pillis, P. Altrock, R. Rockne

• From Ecology to Cancer Biology and Back Again
  Guest Editors: Fred Adler, Sarah Amend, Chris Whelan

• Frontiers in quantitative cancer modeling
  Guest Editors: Mohit Kumar Jolly, Heiko Enderling

• NEW: Research Fellow in Computational Systems Biology Cancer Research (Simon Mitchell)

• PhD student - Measuring cancer evolution in a changing tumour microenvironment (Xiaowei Jiang)

• Postdoctoral Scholar - Genetics and Genome Sciences (Christopher McFarland)

• Postdoc on colorectal cancer evolution or cancer immunotherapy (Ivana Bozic)

• PhD student in modeling evolution and ecology of cancer (Rob Noble)

• Postdoc on cancer/immune modeling and machine learning (Eduardo Sontag)

• PhD candidate/Early Career Researcher: Theory of Stackelberg evolutionary games for cancer treatment (Katerina Stankova)

• Early Stage Researcher: Impact of different resistance mechanisms on the outcomes of cancer treatment game (Weini Huang)

• Early Stage Researcher: Evolutionary therapy in ovarian cancer (Ben Werner)

• CDC Steven M. Teutsch Prevention Effectiveness Fellowship

• Mathematical Modeling Expert in Oncology Translational Science (Boehringer Ingelheim)

• Research Associate - Biostatistician (University of Manchester)

• Postdoctoral Fellow in Cancer Resistance Modeling, Pfizer (Blerta Shtylla)

• Director Quantitative Clinical Pharmacology, Oncology

• Principal Scientist – Oncology PK/PD Modelling (Boehringer Ingelheim)

• Biosimulation Scientist (Physiomics)

• Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)

• Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)

• Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)

• Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)

• Machine Learning / Math Modeling Postdoc (Noemi Andor)

• Cancer immunotherapy / systems bio postdoc (Elana J Fertig)

• Integrated Math Oncology Ph.D. (Moffitt)

• Integrated Math Oncology Postdoc (Sandy Anderson)

• Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)

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