This week in MathOnco 157
Tissue architecture, anti-VEGF, hematopoiesis, super-linear growth, radiation therapy
“This week in Mathematical Oncology” — Newsletter
Apr. 8, 2021
>
jeffrey.west@moffitt.org
>
From the editor:
Today’s newsletter features articles on anti-VEGF therapy, hematopoiesis, one of my own on spatial constraints, super-linear growth, radiation therapy and more.
We also started featuring cover artwork on the newsletter’s homepage. Scroll down to view the first submission!
Enjoy,
-Jeffrey West
Normal tissue architecture determines the evolutionary course of cancer
Jeffrey West, Ryan O. Schenck, Chandler Gatenbee, Mark Robertson-Tessi & Alexander R. A. AndersonProliferation Saturation Index to Characterize Response to RT and Evaluate Altered Fractionation in Head and Neck Cancer
Mohammad U. Zahid, Abdallah S.R. Mohamed, Kujtim Latifi, Anupam Rishi, Louis B. Harrison, Clifton D. Fuller, Eduardo G. Moros, Jimmy J. Caudell, Heiko EnderlingMechanistic insights into the heterogeneous response to anti‐VEGF treatment in tumors
Ding Li, Stacey D. FinleyTowards an Image-Informed Mathematical Model of In Vivo Response to Fractionated Radiation Therapy
David A. Hormuth II, Angela M. Jarrett, Tessa Davis, Thomas E. YankeelovMultistage feedback-driven compartmental dynamics of hematopoiesis
Nathaniel Vincent Mon Père, Tom Lenaerts, Jorge Manuel dos Santos Pacheco, David DingliGroup phenotypic composition in cancer
Jean-Pascal Capp, James DeGregori, Aurora M Nedelcu, Antoine M Dujon, Justine Boutry, Pascal Pujol, Catherine Alix-Panabières, Rodrigo Hamede, Benjamin Roche, Beata Ujvari, Andriy Marusyk, Robert Gatenby, Frédéric Thomas
COSINE: A Web Server for Clonal and Subclonal Structure Inference and Evolution in Cancer Genomics
Xiguo Yuan, Yuan Zhao, Yang Guo, Linmei Ge, Wei Liu, Shiyu Wen, Qi Li, Zhangbo Wan, Peina Zheng, Tao Guo, Zhida Li, Martin Peifer, Yupeng CunSuper-Linear Growth Reveals the Allee Effect in Tumors
Youness Azimzade, Abbas Ali Saberi, Robert A. Gatenby
1. Rethinking angiogenesis
The Mathematical Oncology Blog
Youness Azimzade: “What are the dynamics of angiogenesis during tumor growth? Are tumors well-vascularized after successful angiogenetic switch at early stages or are they continuously struggling to push the oxygen supply limit to grow larger?
The majority of existing literature suggests that small tumors normally experience oxygen shortage. As they become successful in inducing angiogenesis nutrient shortage becomes of less importance. However, you might be surprised to know that one of the greatest figures in tumor angiogenesis research, Judah Folkman, had a different perspective.”
2. A uniform format for manuscript submission
Leonard I. Zon, Jason D. Boisvert, the Zon Lab: “Many scientists spend unnecessary time reformatting papers to submit them to different journals. We propose a uniform submission format that we hope journals will include in their options for submission. Widespread adoption of this uniform submission format could shorten the submission and publishing process, freeing up time for research.”
Atomic Habits:
An Easy & Proven Way to Build Good Habits & Break Bad Ones
James Clear: "If you're having trouble changing your habits, the problem isn't you. The problem is your system. Bad habits repeat themselves again and again not because you don't want to change, but because you have the wrong system for change. You do not rise to the level of your goals. You fall to the level of your systems. Here, you'll get a proven system that can take you to new heights."
Networks in Cancer: From Symmetry Breaking to Targeted Therapy
Guest Editor: Cristian Axenie, Roman Bauer, María Rodríguez MartínezUnderstanding the Evolutionary Dynamics and Ecology of Cancer in Treatment Resistance
Guest Editor: David BasantaMathematical Models of Cellular Immunotherapies in Cancer
Guest Editors: V. Pérez-García, L. de Pillis, P. Altrock, R. RockneFrom Ecology to Cancer Biology and Back Again
Guest Editors: Fred Adler, Sarah Amend, Chris WhelanFrontiers in quantitative cancer modeling
Guest Editors: Mohit Kumar Jolly, Heiko Enderling
The newsletter now has a dedicated homepage (thisweekmathonco.substack.com), which allows us to post cover artwork for each issue. Go explore the previous artwork here, and if you’d like to submit a cover for consideration please reply to this email. We encourage submissions that coincide with the release of a recent paper from your group. Today’s submission is below:
Heber Rocha, Indiana University
The computational model recapitulates the patterns of intratumoral hypoxia. Based on data from a hypoxia fate-mapping system, we developed a computational model to investigate the motility and phenotypic persistence of hypoxic and post-hypoxic cells during tumor progression. The results revealed that post-hypoxic cells have an enhanced persistent migratory phenotype that promotes the formation of invasive structures. In this work, the combination of mathematical modeling with experimental data showed great potential to probe the dynamics and suggest hypotheses. (See preprint here).
NEW: Research Fellow in Computational Systems Biology Cancer Research (Simon Mitchell)
PhD student - Measuring cancer evolution in a changing tumour microenvironment (Xiaowei Jiang)
Postdoctoral Scholar - Genetics and Genome Sciences (Christopher McFarland)
Postdoc on colorectal cancer evolution or cancer immunotherapy (Ivana Bozic)
PhD student in modeling evolution and ecology of cancer (Rob Noble)
Postdoc on cancer/immune modeling and machine learning (Eduardo Sontag)
Early Stage Researcher: Evolutionary therapy in ovarian cancer (Ben Werner)
Mathematical Modeling Expert in Oncology Translational Science (Boehringer Ingelheim)
Research Associate - Biostatistician (University of Manchester)
Postdoctoral Fellow in Cancer Resistance Modeling, Pfizer (Blerta Shtylla)
Principal Scientist – Oncology PK/PD Modelling (Boehringer Ingelheim)
Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
Current subscriber count: 921