This week in MathOnco 159

Parameter estimation, GRNs, chalkboard art, CRC microenvironment, and more

“This week in Mathematical Oncology” — Newsletter
Apr. 22, 2021
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jeffrey.west@moffitt.org
From the editor:

Summary of contents:

  • Parameter estimation

  • Perivascular-niche dynamics

  • The art of writing on chalkboards

  • A new open dataset on impact of microenvironment on CRC growth - useful for model building.

  • GRN’s combined with external cell-cell signaling (stochastic-deterministic modeling)

  • A new postdoc opportunity at Moffitt (Kasia Rejniak)

Enjoy,
-Jeffrey West

  1. Standing Variations Modeling Captures Inter-Individual Heterogeneity in a Deterministic Model of Prostate Cancer Response to Combination Therapy
    Harsh Vardhan Jain, Inmaculada C. Sorribes, Samuel K. Handelman, Johnna Barnaby, Trachette L. Jackson

  2. Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma
    Amanda Randles, Hans-Georg Wirsching, Jamie A. Dean, Yu-Kang Cheng, Samuel Emerson, Siobhan S. Pattwell, Eric C. Holland, Franziska Michor

  3. High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth
    Chun-Te Chiang, Roy Lau, Ahmadreza Ghaffarizadeh, Matthew Brovold, Dipen Vyas, Edwin F Juárez, Anthony Atala, David B Agus, Shay Soker, Paul Macklin, Daniel Ruderman, Shannon M Mumenthaler

  1. A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis
    Megan K. Franke, Adam L. MacLean

  2. Spatial genomics maps the structure, character and evolution of cancer clones
    Artem Lomakin, Jessica Svedlund, Carina Strell, Milana Gataric, …, Peter J Campbell, Moritz Gerstung, Mats Nilsson, Lucy R Yates

  3. Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are Sparse
    Simona Dalin, Douglas A. Lauffenburger, Michael T. Hemann

  4. Targeting Adaptation to Cancer Treatment by Drug Combinations
    Heping Wang, Augustin Luna, Gonghong Yan, Xubin Li, Ozgun Babur, Gordon B. Mills, Chris Sander, Anil Korkut

  5. A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience
    João P.G. Santos, Kadri Pajo, Daniel Trpevski, Andrey Stepaniuk, Olivia Eriksson, Anu G. Nair, Daniel Keller, Jeanette Hellgren Kotaleski, Andrei Kramer

1. The Art of Mathematics in Chalk
Scientific American

Clara Moskowitz: “As Wynne began to travel to different universities to meet more mathematicians, she discovered how diverse their chalkboard styles are. “Some were very clean and neat and very carefully considered,” she recalls. “And some were just this explosion and chaos. The chalkboards almost felt like portraits of the person and depended on the personality of the mathematician.””

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