This week in MathOnco 162
Personalized breast cancer therapy; spatial cooperation; metronomic therapy; self-assembly; spatio-temporal heterogeneity
“This week in Mathematical Oncology” — Newsletter
May. 13, 2021
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jeffrey.west@moffitt.org
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From the editor:
Summary of contents:
Metronomic chemo & resistance
Spatial cooperation in antibiotic resistance
Self-assembly of tissue sheets, which look like real-life MC Escher patterns (as seen on Twitter)
Spatiotemporal Heterogeneity across Metastases in colorectal cancer
Cover artwork from Xiaoran Lai and Alvaro Köhn-Luque’s recent preprint
Enjoy,
-Jeffrey West
Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer
Maryna Bondarenko, Marion Le Grand, Yuval Shaked, Ziv Raviv, Guillemette Chapuisat, Cécile Carrère, Marie-Pierre Montero, Mailys Rossi, Eddy Pasquier, Manon Carré, Nicolas AndréSpatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress
Anupama Sharma, Kevin B. WoodSpatiotemporal Heterogeneity across Metastases and Organ-Specific Response Informs Drug Efficacy and Patient Survival in Colorectal Cancer
Jiawei Zhou, Quefeng Li, Yanguang CaoEvolution of delayed resistance to immunotherapy in a melanoma responder
David Liu, Jia-Ren Lin, Emily J. Robitschek, Gyulnara G. Kasumova, …, Ryan J. Sullivan, Manolis Kellis, Peter K. Sorger, Genevieve M. BolandAn In Silico Glioblastoma Microenvironment Model Dissects the Immunological Mechanisms of Resistance to PD‐1 Checkpoint Blockade Immunotherapy
Zhuoyu Zhang, Lunan Liu, Chao Ma, Xin Cui, Raymond H. W. Lam, Weiqiang Chen
A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy
Xiaoran Lai, Håkon A. Taskén, Torgeir Mo, Simon W. Funke, Arnoldo Frigessi, Marie E. Rognes, Alvaro Köhn-LuqueSelf-assembly of tessellated tissue sheets by growth and collision
Matthew A Heinrich, Ricard Alert, Abraham E. Wolf, Andrej Kosmrlj, Daniel J. CohenThe adaptive potential of non-heritable somatic mutations
Paco Majic, E. Yagmur Erten, Joshua L. PayneVaccination strategies when vaccines are scarce: On conflicts between reducing the burden and avoiding the evolution of escape mutants
Félix Geoffroy, Arne Traulsen, Hildegard Uecker
1. Linear mixed effects models: intro examples in R
by Roseanna Gamlen-Greene
2. Postdocs’ advice on pursuing a research career in academia: A qualitative analysis of free-text survey responses
by Suwaiba Afonja, Damonie G. Salmon, Shadelia I. Quailey, W. Marcus Lambert
“This current study amasses the guidance and recommendations of 994 postdocs on pursuing an academic career. Our objectives are: 1. To understand how postdoctoral research trainees perceive the benefits and challenges of pursuing an academic research career; 2. To provide ways to overcome these challenges.”
The newsletter now has a dedicated homepage (thisweekmathonco.substack.com), which allows us to post cover artwork for each issue. Go explore the previous artwork here, and if you’d like to submit a cover for consideration please reply to this email. We encourage submissions that coincide with the release of a recent paper from your group. Today’s submission is below:
Caption: “Patient-specific outcome after a single chemotherapy shot in a heterogenous breast tumour. Simulated using a parallel solver of a stochastic, hybrid cellular automata. Background colors indicate oxygen pressure in the tumor tissue while cancer cells are represented by black dots.” Created by Xiaoran Lai and Alvaro Köhn-Luque, submitted in conjunction with their recent preprint, found here.
Networks in Cancer: From Symmetry Breaking to Targeted Therapy
Guest Editor: Cristian Axenie, Roman Bauer, María Rodríguez MartínezUnderstanding the Evolutionary Dynamics and Ecology of Cancer in Treatment Resistance
Guest Editor: David BasantaFrom Ecology to Cancer Biology and Back Again
Guest Editors: Fred Adler, Sarah Amend, Chris WhelanFrontiers in quantitative cancer modeling
Guest Editors: Mohit Kumar Jolly, Heiko Enderling
Senior Quantitative Systems Pharmacologist, Pfizer Oncology (Blerta Shtylla)
Mathematical Immuno-Oncology postdoc (Kasia Rejniak, Moffitt)
Research Fellow in Computational Systems Biology Cancer Research (Simon Mitchell)
PhD student - Measuring cancer evolution in a changing tumour microenvironment (Xiaowei Jiang)
Postdoctoral Scholar - Genetics and Genome Sciences (Christopher McFarland)
Postdoc on colorectal cancer evolution or cancer immunotherapy (Ivana Bozic)
Postdoc on cancer/immune modeling and machine learning (Eduardo Sontag)
Early Stage Researcher: Evolutionary therapy in ovarian cancer (Ben Werner)
Mathematical Modeling Expert in Oncology Translational Science (Boehringer Ingelheim)
Research Associate - Biostatistician (University of Manchester)
Principal Scientist – Oncology PK/PD Modelling (Boehringer Ingelheim)
Postdoctoral Research Position in Computational Immunology (Sylvain Cussat-Blanc)
Systems Biology Modeler Positions in Biopharma Consulting Company (Helen Moore)
Computational Approaches to Breast Cancer Evolution - Postdoc (Marc Ryser)
Math/statistical models of stem cell lineage dynamics and cancer genomics - Postdoc (Adam MacLean)
Postdoctoral Research Position in Computational Oncology (Tom Yankeelov)
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