This week in MathOnco 162

Personalized breast cancer therapy; spatial cooperation; metronomic therapy; self-assembly; spatio-temporal heterogeneity

“This week in Mathematical Oncology” — Newsletter
May. 13, 2021
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jeffrey.west@moffitt.org
From the editor:

Summary of contents:

  • Metronomic chemo & resistance

  • Spatial cooperation in antibiotic resistance

  • Self-assembly of tissue sheets, which look like real-life MC Escher patterns (as seen on Twitter)

  • Spatiotemporal Heterogeneity across Metastases in colorectal cancer

  • Cover artwork from Xiaoran Lai and Alvaro Köhn-Luque’s recent preprint

    Enjoy,
    -Jeffrey West

  1. Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer
    Maryna Bondarenko, Marion Le Grand, Yuval Shaked, Ziv Raviv, Guillemette Chapuisat, Cécile Carrère, Marie-Pierre Montero, Mailys Rossi, Eddy Pasquier, Manon Carré, Nicolas André

  2. Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress
    Anupama Sharma, Kevin B. Wood

  3. Spatiotemporal Heterogeneity across Metastases and Organ-Specific Response Informs Drug Efficacy and Patient Survival in Colorectal Cancer
    Jiawei Zhou, Quefeng Li, Yanguang Cao

  4. Evolution of delayed resistance to immunotherapy in a melanoma responder
    David Liu, Jia-Ren Lin, Emily J. Robitschek, Gyulnara G. Kasumova, …, Ryan J. Sullivan, Manolis Kellis, Peter K. Sorger, Genevieve M. Boland

  5. An In Silico Glioblastoma Microenvironment Model Dissects the Immunological Mechanisms of Resistance to PD‐1 Checkpoint Blockade Immunotherapy
    Zhuoyu Zhang, Lunan Liu, Chao Ma, Xin Cui, Raymond H. W. Lam, Weiqiang Chen

  1. A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy
    Xiaoran Lai, Håkon A. Taskén, Torgeir Mo, Simon W. Funke, Arnoldo Frigessi, Marie E. Rognes, Alvaro Köhn-Luque

  2. Self-assembly of tessellated tissue sheets by growth and collision
    Matthew A Heinrich, Ricard Alert, Abraham E. Wolf, Andrej Kosmrlj, Daniel J. Cohen

  3. The adaptive potential of non-heritable somatic mutations
    Paco Majic, E. Yagmur Erten, Joshua L. Payne

  4. Vaccination strategies when vaccines are scarce: On conflicts between reducing the burden and avoiding the evolution of escape mutants
    Félix Geoffroy, Arne Traulsen, Hildegard Uecker

1. Linear mixed effects models: intro examples in R
by Roseanna Gamlen-Greene

2. Postdocs’ advice on pursuing a research career in academia: A qualitative analysis of free-text survey responses
by Suwaiba Afonja, Damonie G. Salmon, Shadelia I. Quailey, W. Marcus Lambert
“This current study amasses the guidance and recommendations of 994 postdocs on pursuing an academic career. Our objectives are: 1. To understand how postdoctoral research trainees perceive the benefits and challenges of pursuing an academic research career; 2. To provide ways to overcome these challenges.”

The newsletter now has a dedicated homepage (thisweekmathonco.substack.com), which allows us to post cover artwork for each issue. Go explore the previous artwork here, and if you’d like to submit a cover for consideration please reply to this email. We encourage submissions that coincide with the release of a recent paper from your group. Today’s submission is below:

Caption: “Patient-specific outcome after a single chemotherapy shot in a heterogenous breast tumour. Simulated using a parallel solver of a stochastic, hybrid cellular automata. Background colors indicate oxygen pressure in the tumor tissue while cancer cells are represented by black dots.” Created by Xiaoran Lai and Alvaro Köhn-Luque, submitted in conjunction with their recent preprint, found here.

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