This week in MathOnco 176
Tumor hypoxia, coexistence mechanisms, hematopoietic evolution, allee effect, evolutionary disease dynamics, somatic evolution, branching populations, and more...
“This week in Mathematical Oncology” — Newsletter
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mathematical-oncology.org
August 26, 2021
From the editor:
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jeffrey.west@moffitt.org
It seems like science often follows a yearly cycle: Write up new results during Fall, preprint by winter, back from review by Spring, respond to reviews over summer, and published by Fall.
All that to say: this issue is packed. Tumor hypoxia, coexistence mechanisms, hematopoietic evolution, allee effect, evolutionary disease dynamics, somatic evolution, branching populations, and more...
- Jeffrey West
A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fatemapping and computational modeling
Heber L. Rocha, Ines Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul MacklinEstrogen as an Essential Resource and the Coexistence of ER+ and ER– Cancer Cells
Irina Kareva, Joel S. BrownThe evolution of hematopoietic cells under cancer therapy
Oriol Pich, Albert Cortes-Bullich, Ferran Muiños, Marta Pratcorona, Abel Gonzalez-Perez, Nuria Lopez-BigasIs the allee effect relevant to stochastic cancer model?
Mrinmoy Sardar, Subhas KhajanchiModeling the effects of EMT-immune dynamics on carcinoma disease progression
Daniel R. Bergman, Matthew K. Karikomi, Min Yu, Qing Nie, Adam L. MacLeanModeling Tumor Growth and Treatment Resistance Dynamics Characterizes Different Response to Gefitinib or Chemotherapy in Non-Small Cell Lung Cancer
Mario Nagase, Sergey Aksenov, Hong Yan, James Dunyak, Nidal Al-HunitiEvolutionary dynamics of cancer multidrug resistance in response to olaparib and photodynamic therapy
Baglo Yan, Aaron J. Sorrin, Pu Xiaocong, Liu Cindy, Jocelyn Reader, Dana M. Roque, Huang-Chiao HuangMachine learning is a powerful tool to study the effect of cancer on species and ecosystems
Antoine M. Dujon, Marion Vittecoq, Georgina Bramwell, Frédéric Thomas, Beata UjvariThe Value of Treating Cancer as an Evolutionary Disease
James Shapiro, Denis Noble
Survival in Branching Cellular Populations
Adam S. Bryant, Maxim O. LavrentovichA DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia
Giulia L. Celora, Samuel B. Bader, Ester M. Hammond, Philip K. Maini, Joe Pitt-Francis, Helen M. ByrneSomatic mutation rates scale with lifespan across mammals
Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, …, Peter J. Campbell, Elizabeth P. Murchison, Michael R. Stratton, Iñigo Martincorena
An illustrated tutorial
@ATJCagan, Twitter.com
“I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals.’ In this paper we provide an unprecedented description of somatic mutation across mammals.”
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Caption: Fate-mapping intratumoral hypoxia allows the tracing of post-hypoxic cells. This simulation shows post-hypoxic invasive plumes (green cells) in a viable region (red cells), and in the center appears the necrotic core (blue cells). For more details, see here. You also can try this model yourself in the cloud-hosted version.
Created by: Heber Rocha (@HeberLRocha) & Ines Godet (@InesGodet)
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