This week in MathOnco 179

Organoid shape dynamics, modeling survival, plasticity, cooperation/competition, cell communication, spatial interactions, and more

“This week in Mathematical Oncology” — Newsletter
September 16, 2021

From the editor:


This week’s edition includes papers on modeling survival, plasticity, cooperation/competition, cell communication, spatial interactions, and more… Enjoy!

- Jeffrey West

  1. Cell competition, cooperation, and cancer
    Fabio Marongiu, Samuele Cheri, Ezio Laconi

  2. Patient-Specific Cell Communication Networks Associate With Disease Progression in Cancer
    David L. Gibbs, Boris Aguilar, Vésteinn Thorsson, Alexander V. Ratushny, Ilya Shmulevich

  3. Struggle within: evolution and ecology of somatic cell populations
    Bartlomiej Swiatczak

  4. Evaluation of Classical Mathematical Models of Tumor Growth Using an On-Lattice Agent-Based Monte Carlo Model
    Samuel Ruiz-Arrebola, Damián Guirado, Mercedes Villalobos, Antonio M. Lallena

  5. Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations
    Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, …, Anthony Letai, Joan Montero, Réka Albert, Nikhil Wagle

  6. Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma
    Nicholas H. Chakiryan, Gregory J. Kimmel, Youngchul Kim, Joseph O. Johnson, …, Liang Wang, James J. Mulé, Philipp M. Altrock, Brandon J. Manley

  7. Modeling Cancer Immunoediting in Tumor Microenvironment with System Characterization through the Ising-model Hamiltonian
    Alfonso Rojas-Domínguez, Renato Arroyo-Duarte, Fernando Rincón-Vieyra, Matías Alvarado

  1. Cancer patient survival can be accurately parameterized, revealing time-dependent therapeutic effects and doubling the precision of small trials
    Deborah Plana, Geoffrey Fell, Brian M. Alexander, Adam C. Palmer, Peter K. Sorger

  2. A spatially resolved mechanistic growth law for cancer drug development predicting tumour growing fractions
    Adam Nasim, James Yates, Gianne Derks, Carina Dunlop

  3. Intraspecific Competition and the Promotion of Ecological Specialization
    Abdel H. Halloway, Joel S. Brown

  1. The effects of remote work on collaboration among information workers
    Nature Human Behavior
    Longqi Yang et. al.: The coronavirus disease 2019 (COVID-19) pandemic caused a rapid shift to full-time remote work for many information workers. Viewing this shift as a natural experiment in which some workers were already working remotely before the pandemic enables us to separate the effects of firm-wide remote work from other pandemic-related confounding factors.

The newsletter now has a dedicated homepage (, which allows us to post cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: Organoids are key experimental models, recapitulating important features of human tissues and enabling high throughput experiments. However, interpretation of these experiments is challenging and often limited to manual, non-standardized, and/or qualitative analysis. To address this issue, we have developed an open-source and modular pipeline (OrgDyn) to quantify organoid shape dynamics from time-series of 2D contour images, using a combination of feature- and model-based approaches. Here we show diverging dynamics of organoid morphology simulated by Fourier modes. To find out more, read our paper here.

Created by: Zaki Hasnain

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