This week in MathOnco 179
Organoid shape dynamics, modeling survival, plasticity, cooperation/competition, cell communication, spatial interactions, and more
“This week in Mathematical Oncology” — Newsletter
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mathematical-oncology.org
September 16, 2021
From the editor:
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jeffrey.west@moffitt.org
Hello,
This week’s edition includes papers on modeling survival, plasticity, cooperation/competition, cell communication, spatial interactions, and more… Enjoy!
- Jeffrey West
Cell competition, cooperation, and cancer
Fabio Marongiu, Samuele Cheri, Ezio LaconiPatient-Specific Cell Communication Networks Associate With Disease Progression in Cancer
David L. Gibbs, Boris Aguilar, Vésteinn Thorsson, Alexander V. Ratushny, Ilya ShmulevichStruggle within: evolution and ecology of somatic cell populations
Bartlomiej SwiatczakEvaluation of Classical Mathematical Models of Tumor Growth Using an On-Lattice Agent-Based Monte Carlo Model
Samuel Ruiz-Arrebola, Damián Guirado, Mercedes Villalobos, Antonio M. LallenaCell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations
Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, …, Anthony Letai, Joan Montero, Réka Albert, Nikhil WagleGeospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma
Nicholas H. Chakiryan, Gregory J. Kimmel, Youngchul Kim, Joseph O. Johnson, …, Liang Wang, James J. Mulé, Philipp M. Altrock, Brandon J. ManleyModeling Cancer Immunoediting in Tumor Microenvironment with System Characterization through the Ising-model Hamiltonian
Alfonso Rojas-Domínguez, Renato Arroyo-Duarte, Fernando Rincón-Vieyra, Matías Alvarado
Cancer patient survival can be accurately parameterized, revealing time-dependent therapeutic effects and doubling the precision of small trials
Deborah Plana, Geoffrey Fell, Brian M. Alexander, Adam C. Palmer, Peter K. SorgerA spatially resolved mechanistic growth law for cancer drug development predicting tumour growing fractions
Adam Nasim, James Yates, Gianne Derks, Carina DunlopIntraspecific Competition and the Promotion of Ecological Specialization
Abdel H. Halloway, Joel S. Brown
The effects of remote work on collaboration among information workers
Nature Human Behavior
Longqi Yang et. al.: “The coronavirus disease 2019 (COVID-19) pandemic caused a rapid shift to full-time remote work for many information workers. Viewing this shift as a natural experiment in which some workers were already working remotely before the pandemic enables us to separate the effects of firm-wide remote work from other pandemic-related confounding factors.”
The newsletter now has a dedicated homepage (thisweekmathonco.substack.com), which allows us to post cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.
Caption: Organoids are key experimental models, recapitulating important features of human tissues and enabling high throughput experiments. However, interpretation of these experiments is challenging and often limited to manual, non-standardized, and/or qualitative analysis. To address this issue, we have developed an open-source and modular pipeline (OrgDyn) to quantify organoid shape dynamics from time-series of 2D contour images, using a combination of feature- and model-based approaches. Here we show diverging dynamics of organoid morphology simulated by Fourier modes. To find out more, read our paper here.
Created by: Zaki Hasnain
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