This week in MathOnco 180
Reversible resistance, non-darwinian evolution, drug synergy, tumor heterogeneity, traveling wave trade-offs
“This week in Mathematical Oncology” — Sept. 23, 2021
From the editor:
This week’s edition includes papers on reversible resistance, non-darwinian evolution, drug synergy, tumor heterogeneity, traveling wave trade-offs and more.
A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells
Sarthak Sahoo, Ashutosh Mishra, Harsimran Kaur, Kishore Hari, Srinath Muralidharan, Susmita Mandal, Mohit Kumar Jolly
Bridging Tumorigenesis and Therapy Resistance With a Non-Darwinian and Non-Lamarckian Mechanism of Adaptive Evolution
Francesco Catania, Beata Ujvari, Benjamin Roche, Jean-Pascal Capp, Frédéric Thomas
Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?
Irina Kareva, Kimberly A. Luddy, Cliona O’Farrelly, Robert A. Gatenby, Joel S. Brown
Modeling the synergistic properties of drugs in hormonal treatment for prostate cancer
Trevor Reckell, Kyle Nguyen, Tin Phan, Sharon Crook, Eric J. Kostelich, Yang Kuang
A narrative review of tumor heterogeneity and challenges to tumor drug therapy
Liang Zhu, Minlin Jiang, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Yayi He
Deep learning prediction of patient response time course from early data via neural-pharmacokinetic/pharmacodynamic modelling
James Lu, Brendan Bender, Jin Y. Jin, Yuanfang Guan
Computational capability of ecological dynamics
Masayuki Ushio, Kazufumi Watanabe, Yasuhiro Fukuda, Yuji Tokudome, Kohei Nakajima
Supervised Hierarchical Autoencoders for Multi-Omics Integration in Cancer Survival Models
David Wissel, Daniel Rowson, Valentina Boeva
Trade-offs between chemotaxis and proliferation shape the phenotypic structuring of invading waves
Tommaso Lorenzi, Kevin J Painter
Evaluating the impact of ideation and actualization of multidisciplinary research
Andrea Armani & Jerry Lee: “Global events in the past year has made prescient a long-standing debate on the definition and suitability of impact and novelty as criteria for publication in selective journals. Reflecting on this issue, Prof Andrea Armani and Prof Jerry Lee argue that rigour and reproducibility is, in fact, more crucial.”
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Caption: Cells undergoing metastasis can acquire both drug resistance and migratory properties. This is a multi-scale process, illustrated here for ER+ breast cancer. On the cell scale, cells transition between different phenotypes in the phenotypic landscape due to noise and the administration of drugs (Left). This defines the cell’s adaptive level of drug resistance and its position along the epithelial-mesenchymal transition axis (EMT). On the population scale, this subsequently manifests in multiple parallel paths to long-term resistance in a given cancer cell population (pre-existing reversibly resistant cells, stochastic switching and dynamic equilibrium, and drug-induced plasticity; Right). To learn more, check out our recent paper here.
Created by: Atchuta Duddu
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