This week in MathOnco 180

Reversible resistance, non-darwinian evolution, drug synergy, tumor heterogeneity, traveling wave trade-offs

“This week in Mathematical Oncology” — Sept. 23, 2021

From the editor:

This week’s edition includes papers on reversible resistance, non-darwinian evolution, drug synergy, tumor heterogeneity, traveling wave trade-offs and more.


Jeffrey West

  1. A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells
    Sarthak Sahoo, Ashutosh Mishra, Harsimran Kaur, Kishore Hari, Srinath Muralidharan, Susmita Mandal, Mohit Kumar Jolly

  2. Bridging Tumorigenesis and Therapy Resistance With a Non-Darwinian and Non-Lamarckian Mechanism of Adaptive Evolution
    Francesco Catania, Beata Ujvari, Benjamin Roche, Jean-Pascal Capp, Frédéric Thomas

  3. Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?
    Irina Kareva, Kimberly A. Luddy, Cliona O’Farrelly, Robert A. Gatenby, Joel S. Brown

  4. Modeling the synergistic properties of drugs in hormonal treatment for prostate cancer
    Trevor Reckell, Kyle Nguyen, Tin Phan, Sharon Crook, Eric J. Kostelich, Yang Kuang

  5. A narrative review of tumor heterogeneity and challenges to tumor drug therapy
    Liang Zhu, Minlin Jiang, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Yayi He

  6. Deep learning prediction of patient response time course from early data via neural-pharmacokinetic/pharmacodynamic modelling
    James Lu, Brendan Bender, Jin Y. Jin, Yuanfang Guan

  1. Computational capability of ecological dynamics
    Masayuki Ushio, Kazufumi Watanabe, Yasuhiro Fukuda, Yuji Tokudome, Kohei Nakajima

  2. Supervised Hierarchical Autoencoders for Multi-Omics Integration in Cancer Survival Models
    David Wissel, Daniel Rowson, Valentina Boeva

  3. The Paradox of the Plankton: Coexistence of Structured Microbial Communities
    Alberto Scarampi

  4. Trade-offs between chemotaxis and proliferation shape the phenotypic structuring of invading waves
    Tommaso Lorenzi, Kevin J Painter

  1. Evaluating the impact of ideation and actualization of multidisciplinary research
    Communications Physics
    Andrea Armani & Jerry Lee: “Global events in the past year has made prescient a long-standing debate on the definition and suitability of impact and novelty as criteria for publication in selective journals. Reflecting on this issue, Prof Andrea Armani and Prof Jerry Lee argue that rigour and reproducibility is, in fact, more crucial.”

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Caption: Cells undergoing metastasis can acquire both drug resistance and migratory properties. This is a multi-scale process, illustrated here for ER+ breast cancer. On the cell scale, cells transition between different phenotypes in the phenotypic landscape due to noise and the administration of drugs (Left). This defines the cell’s adaptive level of drug resistance and its position along the epithelial-mesenchymal transition axis (EMT). On the population scale, this subsequently manifests in multiple parallel paths to long-term resistance in a given cancer cell population (pre-existing reversibly resistant cells, stochastic switching and dynamic equilibrium, and drug-induced plasticity; Right). To learn more, check out our recent paper here.

Created by: Atchuta Duddu

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