This week in MathOnco 193
Intermittent & adaptive therapy, sensitivity analysis, tissue organization, CAR-T cells, and more
“This week in Mathematical Oncology” — Jan. 20, 2022
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mathematical-oncology.org
From the editor:
Welcome to another edition of This week in MathOnco! Thanks for those of you who responded to our survey, we are eager to share some of the results with you soon. Until then, there’s still time to
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Please be sure to check out the
Astellas internship
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Jeffrey West
jeffrey.west@moffitt.org
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
Calum Gabbutt, Ryan O. Schenck, Daniel J. Weisenberger, Christopher Kimberley, …, Simon J. Leedham, Alexander R. A. Anderson, Trevor A. Graham, Darryl ShibataInterconnected high-dimensional landscapes of epithelial–mesenchymal plasticity and stemness in cancer
Sarthak Sahoo, Bazella Ashraf, Atchuta Srinivas Duddu, Adrian Biddle & Mohit Kumar JollyCancer risk across mammals
Orsolya Vincze, Fernando Colchero, Jean-Francois Lemaître, Dalia A. Conde, …, Amy M. Boddy, Carlo C. Maley, Frédéric Thomas, Mathieu GiraudeauSensitivity analysis of agent-based models: a new protocol
Emanuele Borgonovo, Marco Pangallo, Jan Rivkin, Leonardo Rizzo & Nicolaj SiggelkowPerspectives on Virtual (Remote) Clinical Trials as the “New Normal” to Accelerate Drug Development
Demissie Alemayehu, Robert Hemmings, Kannan Natarajan, Satrajit RoychoudhuryMathematical modeling of therapeutic neural stem cell migration in mouse brain with and without brain tumors
Justin Gomez, Nathanael Holmes, Austin Hansen, Vikram Adhikarla, Margarita Gutova, Russell C. Rockne, Heyrim ChoFind the path of least resistance: Adaptive therapy to delay treatment failure and improve outcomes
Craig Gedye, Vishal NavaniComputational Modeling of Chimeric Antigen Receptor (CAR) T-Cell Therapy of a Binary Model of Antigen Receptors in Breast Cancer
Henning Fischel, Tina Giorgadze, Ansel Tessier, Kerri-Ann NortonInvasion front dynamics of interactive populations in environments with barriers
Youness Azimzade
Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
Márton Demeter, Imre Derényi, Gergely J. SzöllősiSpread of New Mutations Through Space
Kyle Shaw, Peter BeerliModeling predicts differences in CAR T cell signaling due to biological variability
Vardges Tserunyan, Stacey D Finley
The Cancer History Project
Building a living record of progress against cancer: “Forty-nine years and a few days after the signing of the National Cancer Act of 1971, we launched the Cancer History Project. One year and 11,894 articles later, we have built a shared, collaborative, and unprecedented resource.”
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.
Caption: This artwork is a representation of our recently published work in Nature Biotechnology illustrating the use of fluctuating methylation clocks (FMC) to reconstruct human somatic cell lineages. The artwork is a superimposed mixture of some of the mathematics governing methylation, its derivation, the inference method, and the informative fluctuating CpG (fCpG) distribution. If you look closely, the fill of the histogram is a gradient where on the left to right you have 0%, 50% (middle), and 100% methylated loci. This fill on the fCpG distribution is represented in Figure 1A of the manuscript. We found that these fCpGs are informative across tissues and cell types having applied our methodology and theory in the Colon, Small Intestines, Endometrium, and human blood.
Created by: Ryan Schenck & Calum Gabbutt
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