This week in MathOnco 195
Novelty in science, dose dependence, higher-order spatial interactions, spatial transcriptomics, predictive modeling, and more
“This week in Mathematical Oncology” — Feb. 3, 2022
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mathematical-oncology.org
From the editor:
Dear readers, please enjoy this week’s collection of articles on topics like novelty in science, dose dependence, higher-order spatial interactions, spatial transcriptomics, predictive modeling, and more!
Jeffrey West
jeffrey.west@moffitt.org
Higher-order effects, continuous species interactions, and trait evolution shape microbial spatial dynamics
Anshuman Swain, Levi Fussell, William F. FaganAnalysis and Visualization of Spatial Transcriptomic Data
Boxiang Liu, Yanjun Li, Liang ZhangDose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy
Alexander B. Brummer, Xin Yang, Eric Ma, Margarita Gutova, Christine E. Brown, Russell C. Rockne
Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes
Arran Hodgkinson, Dumitru Trucu, Matthieu Lacroix, Laurent Le Cam, Ovidiu RadulescuHow to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells? A case study in patient-derived glioblastoma organoids
Weronika Gąska, Christer Lokh, Maikel Verduin, Marc Vooijs, Rachel Cavill, Kateřina StaňkováMapping Spatiotemporal Heterogeneity in Tumour Progression by Integrating High-Throughput Imaging and Omics Analysis
Pooja Annasaheb Patkulkar, Ayalur Raghu Subbalakshmi, Mohit Kumar Jolly, Sanhita SinharayUsing mathematical modelling to identify data requirements for increased prediction accuracy in radiotherapy
Thomas D. Lewin, Philip K. Maini, Eduardo G. Moros, Jimmy Caudell, Heiko Enderling, Helen M. Byrne
My LaTeX Workflow – Editor
The “My LaTeX Workflow” Series
Alexander Zeilmann: “This post is part of my series on my LaTeX workflow. In it, I explain which editor I use and how I configured it. I will start with a few general-purpose settings and useful extensions before diving into the LaTeX specific configurations.”Novelty in Science: A guide for reviewers
Perceiving Systems Blog
Michael J. Black: “Reviewers have strong ideas about what makes a paper acceptable in top conferences like CVPR. They know that getting into such conferences is hard and that getting a paper in is prestigious. So, the papers that get in must be really special. This is true, but what makes a paper special? A key focus of many reviewers is novelty. But what is novelty in science?”
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.
Caption: Understanding the evolution and stability of diversity in microbial communities, especially in the presence of ample antagonistic interactions, has been an important problem in theoretical biology. In our recent paper, we explored the dynamics of diversity and stability in microbial assemblages using a trait-focused agent-based model that takes into account a continuous species space, higher-order interaction among microbes and a range of mutational regimes. On this cover, we depict the growth of their microbial model in the space around the text. Color is used to represent microbial species, and the colors change as the microbes interact and mutate on the lattice. The particular parameters for this simulation result in a static and stable final state, but simple interaction rules embedded in their model can capture a range of dynamic behaviours. Although our model was aimed at answering questions in microbial assemblages, several elements, such as the inclusion of direct and indirect ecological interactions, the interplay of multiple cell lineages, and spatio-temporal heterogeneity in the community, make the model a general framework for investigating diverse biological systems, including oncological ones.
Created by: Anshuman Swain & Levi Fussell
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