This week in MathOnco 203
Estrogen paradox, stochastic fluctuations, plasticity, and more.
“This week in Mathematical Oncology” — Mar. 31, 2022
From the editor:
Today’s edition features a mathematical model of the estrogen paradox (see also the cover image this week), a roadmap paper on plasticity in cancer, stochastic fluctuations in non-genetic evolution, and more.
Mathematical model for the estrogen paradox in breast cancer treatment
Rachid Ouifki, Segun I. Oke
Roadmap on plasticity and epigenetics in cancer
Jasmine Foo, David Basanta, Russell C. Rockne, Carly Strelez, …, Mary Spilker, Blerta Shtylla, Mark Robertson-Tessi, Alexander R A Anderson
A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy
Xiaoran Lai, Håkon A. Taskén, Torgeir Mo, Simon W. Funke, Arnoldo Frigessi, Marie E. Rognes, Alvaro Köhn-Luque
Adversarial attacks and adversarial robustness in computational pathology
Narmin Ghaffari Laleh, Daniel Truhn, Gregory Patrick Veldhuizen, Tianyu Han, Marko van Treeck, Roman D. Buelow, Rupert Langer, Bastian Dislich, Peter Boor, Volkmar Schulz, Jakob Nikolas Kather
CNETML: Maximum likelihood inference of phylogeny from copy number profiles of spatio-temporal samples
Bingxin Lu, Kit Curtius, Trevor A Graham, Ziheng Yang, Chris P Barnes
Stochastic fluctuations drive non-genetic evolution of proliferation in clonal cancer cell populations
Carmen Ortega-Sabater, Gabriel F. Calvo, Jelena Dinić, Ana Podolski-Renic, Milica Pesic, Víctor M. Pérez-García
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Caption: This artwork is based on a bifurcation diagram that emerged from our paper on the Estrogen paradox that was recently published in the Journal of Mathematical Biology. In this paper, we proposed a novel mathematical model that accounts for the interactions between cancer cells, the estrogen hormone and the p53 protein. The model's bifurcation analysis suggests that the estrogen paradox could be the result of an interplay between estrogen and p53. It further provides explicit conditions under which the paradoxical effect of long-term treatment may be prevented. Active-tumor cells are eliminated in the purple areas and persist in the red and green ones. To reflect the paradox our paper addresses, the bifurcation diagrams have been arranged around a Penrose triangle.
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