This week in MathOnco 204

Immunosuppression, pharmacometrics, chemo-cachexia, liquid biopsies, model selection

“This week in Mathematical Oncology” — Apr. 7, 2022

> mathematical-oncology.org

From the editor:

Today’s issue contains publications on immunosuppression, pharmacometrics, chemo-cachexia, liquid biopsies, model selection, and more. Enjoy!

Jeffrey West
jeffrey.west@moffitt.org

1. Immunosuppressive niche engineering at the onset of human colorectal cancer
   Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, …, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson

2. Pharmacometrics Golems: Exposure-Response Models in Oncology
   Akash Khandelwal, Ana-Marija Grisic, Jonathan French, Karthik Venkatakrishnan

3. Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment
   Suzan Farhang-Sardroodi, Michael A. La Croix, Kathleen P. Wilkie

4. Clinical Applications of Liquid Biopsy in Prostate Cancer: From Screening to Predictive Biomarker
   Filip Ionescu, Jingsong Zhang, Liang Wang

1. A simple and viable approach to estimate population trends
   Mario Schlemmer

2. Treatment response prediction: Is model selection unreliable?
   David Augustin, Ken Wang, Antje-Christine Walz, Ben Lambert, Michael Clerx, Martin Robinson, David Gavaghan

3. Informative and adaptive distances and summary statistics in sequential approximate Bayesian computation
   Yannik Schälte, Jan Hasenauer

4. Do amplifiers of selection maximise average fitness?
   Nikhil Sharma, Arne Traulsen

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: In our recent paper, we examined the tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma in colorectal cancer using a combination of computational modeling, ecological analysis of digital pathology data, and neoantigen prediction. The artwork shows artistically arranged quadrat count maps of species abundance on a histology slide which we used to dissect the tumor ecology during tumorigenesis (blue=low; red=high). Our work provides evidence that it is the construction of an immunosuppressive niche by the tumor, rather than PD-L1 overexpression, that is the predominant pathway to overcome immune predation during tumor initiation in colorectal cancer.

Created by: Sandy Anderson, Maximilian Strobl, Jeffrey West, Chandler Gatenbee

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