This week in MathOnco 213

Bone healing, T-cell cooperation, toxicology, imaging math models, the tumor ecosystem

Jeffrey West

Maximilian Strobl

, and

Sandy Anderson

Jun 9

`“This week in Mathematical Oncology” — June 9, 2022`

`> mathematical-oncology.org`

`From the editor:`

Today we feature papers on bone healing, T-cell cooperation, toxicology, imaging math models, the tumor ecosystem and more. Enjoy,

Jeffrey West jeffrey.west@moffitt.org

"Seek simplicity, but distrust it." -A. N. Whitehead

Integrated computational and in vivo models reveal key insights into macrophage behavior during bone healing
Etienne Baratchart, Chen Hao Lo, Conor C. Lynch, David Basanta
High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
Gustave Ronteix, Shreyansh Jain, Christelle Angely, Marine Cazaux, Roxana Khazen, Philippe Bousso, Charles N. Baroud
Challenges faced when modeling clinical toxicology and toxinology events
Stephen Duffull, Geoff Isbister
Opportunities for improving brain cancer treatment outcomes through imaging-based mathematical modeling of the delivery of radiotherapy and immunotherapy
David A. Hormuth II, Maguy Farhat, Chase Christenson, Brandon Curl, C. Chad Quarles, Caroline Chung, Thomas E. Yankeelov
A Theoretical Analysis of the Scale Separation in a Model to Predict Solid Tumour Growth
Bárbarade Melo Quintela, Silvia Hervas-Raluy, Jose Manuel Garcia Aznar, Dawn Walker, Kenneth Y. Wertheim, Marco Viceconti
The theory of tumor ecosystem
Xueman Chen, Erwei Song

Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson
Macrophage sensitivity to microenvironmental cues influences spatial heterogeneity of tumours
Joshua A. Bull, Helen M. Byrne
A lack of distinct cell identities in single-cell measurements: revisiting Waddington’s landscape
Breanne Sparta, Timothy Hamilton, Serena Hughes, Eric J. Deeds

New area of study aims to use tumor evolution to fight cancer
AACR Meeting News
”Tumor evolution is moving from scientific curiosity toward clinical tool. Recent findings link mutational burden in normal tissues with tumorigenesis, while ongoing research is examining how tumor evolution can be directed in useful directions. Against this backdrop, the AACR established a Cancer Evolution Working Group in July 2021 and planned a plenary session dedicated to tumor evolution for the final day of this year’s Annual Meeting.”

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: “Hypothesis combination pipeline was built to identify mechanisms able to recapitulate bone injury data. Each node of the flow chart represents a cellular type, orange arrows represent state transition, purple arrows represent stimulation, and tile arrows represent inhibition. In total 18 hypotheses combination were tested against mouse bone injury data, comprising longitudinal quantification of bone cell populations. Each hypothesis combination was formalized by an ordinary-differential equation system, which goodness of fit was assessed and compared to other combinations. This way, one hypothesis combination pertaining to behaviour of osteoblasts, osteoclasts and macrophages was identified to the one recapitulating experimental data the best. Read the paper here.“

Created by: Etienne Baratchart (@MathBioEB)

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