This week in Mathematical Oncology

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This week in MathOnco 213
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This week in MathOnco 213

Bone healing, T-cell cooperation, toxicology, imaging math models, the tumor ecosystem

Jeffrey West
,
Maximilian Strobl
, and
Sandy Anderson
Jun 9
1
Share this post
This week in MathOnco 213
thisweekmathonco.substack.com
“This week in Mathematical Oncology” — June 9, 2022
> mathematical-oncology.org
From the editor:

Today we feature papers on bone healing, T-cell cooperation, toxicology, imaging math models, the tumor ecosystem and more. Enjoy,

Jeffrey West
jeffrey.west@moffitt.org


"Seek simplicity, but distrust it."
-A. N. Whitehead


  1. Integrated computational and in vivo models reveal key insights into macrophage behavior during bone healing
    Etienne Baratchart, Chen Hao Lo, Conor C. Lynch, David Basanta

  2. High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
    Gustave Ronteix, Shreyansh Jain, Christelle Angely, Marine Cazaux, Roxana Khazen, Philippe Bousso, Charles N. Baroud

  3. Challenges faced when modeling clinical toxicology and toxinology events
    Stephen Duffull, Geoff Isbister

  4. Opportunities for improving brain cancer treatment outcomes through imaging-based mathematical modeling of the delivery of radiotherapy and immunotherapy
    David A. Hormuth II, Maguy Farhat, Chase Christenson, Brandon Curl, C. Chad Quarles, Caroline Chung, Thomas E. Yankeelov

  5. A Theoretical Analysis of the Scale Separation in a Model to Predict Solid Tumour Growth
    Bárbarade Melo Quintela, Silvia Hervas-Raluy, Jose Manuel Garcia Aznar, Dawn Walker, Kenneth Y. Wertheim, Marco Viceconti

  6. The theory of tumor ecosystem
    Xueman Chen, Erwei Song

  1. Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
    Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson

  2. Macrophage sensitivity to microenvironmental cues influences spatial heterogeneity of tumours
    Joshua A. Bull, Helen M. Byrne

  3. A lack of distinct cell identities in single-cell measurements: revisiting Waddington’s landscape
    Breanne Sparta, Timothy Hamilton, Serena Hughes, Eric J. Deeds

  1. New area of study aims to use tumor evolution to fight cancer
    AACR Meeting News
    ”Tumor evolution is moving from scientific curiosity toward clinical tool. Recent findings link mutational burden in normal tissues with tumorigenesis, while ongoing research is examining how tumor evolution can be directed in useful directions. Against this backdrop, the AACR established a Cancer Evolution Working Group in July 2021 and planned a plenary session dedicated to tumor evolution for the final day of this year’s Annual Meeting.”

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.

Caption: “Hypothesis combination pipeline was built to identify mechanisms able to recapitulate bone injury data. Each node of the flow chart represents a cellular type, orange arrows represent state transition, purple arrows represent stimulation, and tile arrows represent inhibition. In total 18 hypotheses combination were tested against mouse bone injury data, comprising longitudinal quantification of bone cell populations. Each hypothesis combination was formalized by an ordinary-differential equation system, which goodness of fit was assessed and compared to other combinations. This way, one hypothesis combination pertaining to behaviour of osteoblasts, osteoclasts and macrophages was identified to the one recapitulating experimental data the best. Read the paper here.“

Created by: Etienne Baratchart (@MathBioEB)

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

  • PhD position in DFG Research Training Group (RTG 2762) on mathematical modeling of radiotherapy-induced immune responses (Farnoush Farahpour)

2. Conferences / Meetings

  • SABC Meeting: Systems Approaches to Cancer Biology

3. Special issues


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