This week in MathOnco 216
Evolutionary game theory, reaction-diffusion, stochastic control, clinical translation, continuum resistance
“This week in Mathematical Oncology” — June 30, 2022
> mathematical-oncology.org
From the editor:
Today we feature evolutionary game theory, reaction-diffusion, stochastic control, clinical translation, continuum resistance, and more. Enjoy,
Jeffrey West
jeffrey.west@moffitt.org
"Science begins with counting. To understand a phenomenon, a scientist must first describe it; to describe it objectively, he must first measure it.”
- S. Muhkergee
Challenging Standard-of-Care Paradigms in the Precision Oncology Era
Vivek Subbiah, Razelle KurzrockCancer systems epidemiology: Overcoming misconceptions and integrating systems approaches into cancer research
Patricia L. Mabry, Nicolaas P. Pronk, Christopher I. Amos, John S. Witte, Patrick T. Wedlock, Sarah M. Bartsch, Bruce Y. LeeChemChaste: Simulating spatially inhomogeneous biochemical reaction–diffusion systems for modeling cell–environment feedbacks
Connah G M Johnson, Alexander G Fletcher, Orkun S SoyerAnalysis of cancerous tumor growth by the competitive model based on the evolutionary game theory
Atefeh Deris Mahdi Sohrabi-Haghighat
Modelling the mechanical cross-talk between cells and fibrous extracellular matrices using hybrid cellular Potts and molecular dynamics methods
Erika Tsingos, Bente Hilde Bakker, Koen A.E. Keijzer, Hermen Jan Hupkes, Roeland M.H. MerksStochastic optimal control to guide adaptive cancer therapy
MingYi Wang, Jacob G. Scott, Alexander VladimirskyPromoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations
Michael Raatz, Arne TraulsenDiffusion approximations in population genetics and the rate of Muller's ratchet
Camila Braeutigam, Matteo SmerlakEvolutionary dynamics in non-Markovian models of microbial populations
Farshid Jafarpour, Ethan Levien, Ariel AmirEvolving copy number gains promote tumor expansion and bolster mutational diversification
Zicheng Wang, Yunong Xia, Lauren Mills, Athanasios N. Nikolakopoulos, Nicole Maeser, Jason M. Sheltzer, Ruping SunSequential antibiotic therapy in the lab and in the patient
Christin Nyhoegen, Hildegard UeckerDrug-induced adaptation along a resistance continuum in cancer cells
Gustavo Starvaggi Franca, Maayan Baron, Maayan Pour, Benjamin R. King, …, Ayushi Patel, Douglas A. Levine, Timothee Lionnet, Itai Yanai
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia
Nature Cancer: Behind the Paper
Virginia Turati: “ Our results delineate the selection mechanisms operating during induction chemotherapy, emphasizing the importance of cell state in chemo-resistance. This may be particularly relevant when evaluating the appropriateness of targeting particular genetic lesions, and we hope that helping explain treatment failure will eventually lead to more effective therapies.”
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group.
Caption: “The key message of our work ( DOI: 10.1038/s43018-021-00219-3) is that induction chemotherapy in BCP-ALL does not select for genotypes, as it leaves the overall extent of intratumor genetic heterogeneity present in the diagnostic disease unaffected. Instead, it induces canalization (or bottleneck selection) at the level of cell states, which are more heterogeneous than previously appreciated, and partially encoded through aberrant methylation. The idea behind our cover is that a tornado is a metaphor for this biological process of canalization. At the bottom of the image is the tumor cells, heterogeneous in their cell states. As the tornado roams through the tumor with its destructive force, it collects the cells, but some cells, which exist in a resistant cell state, are spared from it. The cover image was entirely computed in R and the code can be found here.”
Created by: Virginia Turati (@TuratiVirginia)
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