This week in MathOnco 219

3D epithelia, combination chemo, androgen deprivation & immunotherapy, spatial modeling in Julia, turnover

“This week in Mathematical Oncology” — July 21, 2022

> mathematical-oncology.org

From the editor:

Today we feature articles on 3D epithelia, combination chemo, androgen deprivation & immunotherapy, spatial modeling in Julia, turnover, and more. Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

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"Somewhere, something incredible is waiting to be known."
- S. Begley

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1. Self-organization in brain tumors: How cell morphology and cell density influence glioma pattern formation
   Sara Jamous, Andrea Comba, Pedro R. Lowenstein, Sebastien Motsch

2. A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia
   Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Samira Anbari, Antonio Tagua, …, Rafael Robles, Alberto Márquez, Javier Buceta, Luis M. Escudero

3. Drug independence and the curability of cancer by combination chemotherapy
   Amy E. Pomeroy, Emmett V. Schmidt, Peter K. Sorger, Adam C. Palmer

4. Combining Androgen Deprivation and Immunotherapy in Prostate Cancer Treatment: A Mechanistic Approach
   Johnna Barnaby, Harsh Vardhan Jain

5. Integrating digital pathology and mathematical modelling to predict spatial biomarker dynamics in cancer immunotherapy
   L. G. Hutchinson, O. Grimm

6. A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells
   Mariangela Russo, Simone Pompei, Alberto Sogari, Mattia Corigliano, …, Federica Di Nicolantonio, Alberto Bardelli, Marco Cosentino Lagomarsino

7. Statistical considerations for analyses of time-to-event endpoints in oncology clinical trials: Illustrations with CAR-T immunotherapy studies
   Yimei Li, Wei-Ting Hwang, Shannon L. Maude, David T. Teachey, …, Hongyan Liu, David L. Porter, Stephan A. Grupp, Pamela A. Shaw

8. J-SPACE: a Julia package for the simulation of spatial models of cancer evolution and of sequencing experiments
   Fabrizio Angaroni, Alessandro Guidi, Gianluca Ascolani, Alberto d’Onofrio, Marco Antoniotti, Alex Graudenzi

1. Scale-free correlations and criticality in explants derived from an orthotopic model of brain cancer
   Kevin B. Wood, Andrea Comba, Sebastien Motsch, Tomás S. Grigera, Pedro Lowenstein

2. Pattern formation and front stability for a moving-boundary model of biological invasion and recession
   Alexander K. Y. Tam, Matthew J. Simpson

3. SHAPR predicts 3D cell shapes from 2D microscopic images
   Dominik J. E. Waibel, Niklas Kiermeyer, Scott Atwell, Ario Sadafi, Matthias Meier, Carsten Marr

4. Turnover shapes evolution of birth and death rates
   Teemu Kuosmanen, Simo Särkkä, Ville Mustonen

5. Tumor subclones, where are you?
   Xianbin Su, Shihao Bai, Gangcai Xie, Yi Shi, Linan Zhao, Guoliang Yang, Futong Tian, Kun-Yan He, Lan Wang, Xiaolin Li, Qi Long, Ze-Guang Han

6. Automatic detection of spatio-temporal signalling patterns in cell collectives
   Paolo Armando Gagliardi, Benjamin Grädel, Marc-Antoine Jacques, Lucien Hinderling, …, Gerald Kastberger, Olivier Pertz, Maciej Dobrzyński

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