This week in MathOnco 227

Experimental design, evolutionary dynamics, spatial heterogeneity, clonal fitness, and more

“This week in Mathematical Oncology” — Sept. 19, 2022

> mathematical-oncology.org

From the editor:

You may have noticed — it’s not Thursday!

We decided to release this week’s edition on Monday to celebrate one of the biggest meetings in Math Onco: Society for Mathematical Biology. To aid in the celebration, Maximilian Strobl has written a blog post describing the past year in Math Onco artwork.

Today’s edition features articles on experimental design, evolutionary dynamics, spatial heterogeneity, clonal fitness, and more.

See you next week on our regularly scheduled Thursday morning,

Jeffrey West
jeffrey.west@moffitt.org

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“When you see a good move, look for a better one.”
-Emanuel Lasker
Mathematician & World Chess Champion

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1. A distinct four-value blood signature of pyrexia under combination therapy of malignant melanoma with dabrafenib and trametinib evidenced by an algorithm-defined pyrexia score
   Hannah Schaefer, Albert Rübben, André Esser, Arturo Araujo, Oana-Diana Persa, Marike Leijs

2. Model-informed experimental design recommendations for distinguishing intrinsic and acquired targeted therapeutic resistance in head and neck cancer
   Santiago D. Cárdenas, Constance J. Reznik, Ruchira Ranaweera, Feifei Song, Christine H. Chung, Elana J. Fertig, Jana L. Gevertz

3. Evolutionary Dynamics Within and Among Competing Groups
   Daniel B. Cooney, Simon A. Levin, Yoichiro Mori, Joshua B. Plotkin

4. Mathematical characterization of population dynamics in breast cancer cells treated with doxorubicin
   Emily Y. Yang, Grant R. Howard, Amy Brock, Thomas E. Yankeelov, Guillermo Lorenzo

5. Facts and hopes on the use of artificial intelligence for predictive immunotherapy biomarkers in cancer
   Narmin Ghaffari Laleh, Marta Ligero, Raquel Perez-Lopez, Jakob N. Kather

6. A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma
   Chay Paterson, Ivana Bozic, Miriam J. Smith, Xanthe Hoad & D. Gareth R. Evans

7. Accurate tumor clonal structures require single-cell analysis
   Xianbin Su, Shihao Bai, Gangcai Xie, Yi Shi, Linan Zhao, Guoliang Yang, Futong Tian, Kun-Yan He, Lan Wang, Xiaolin Li, Qi Long, Ze-Guang Han

1. A Multithreaded Model for Cancer Tissue Heterogeneity: An Application
   Shabnam Choudhury

2. Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancers
   Ming Li, Sisi Xie, Tao Hou, Tong Shao, Jingyu Kuang, Chenyu Lu, Xianling Liu, Lingyun Zhu, Lvyun Zhu

3. Fitness of a clonal population can be inferred from lineage trees without knowledge of the biological details
   Javier Escabi, Sahand Hormoz

1. Behind the newsletter cover:

   Showcasing the creativity of the MathOnco community
   The Mathematical Oncology Blog
   Maximilian Strobl: “It all began with one of those fateful lunchtime conversations. “Wouldn’t it be cool if the mathonco newsletter had cover art? We could showcase cool visualizations created by the community and provide a platform to exchange ideas, tools and examples of mathonco data visualization – or just goofy output from simulations gone wrong.” As with many lunchtime ideas, the concept sounded great, but the work involved seemed a little daunting: sure, it was easy enough to think of a few initial examples, but was it realistic to think we could keep this up every week? Well, we tried – and 67 pieces of artwork later we are still going.“

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Artists: Various; Curated & solicited by Maximilian Strobl (@StroblMAR)

Caption: “It all began with one of those fateful lunchtime conversations. “Wouldn’t it be cool if the mathonco newsletter had cover art?” Well, we tried – and 67 pieces of artwork later we are still going. If you’re interested to learn more about this project and get a behind the scene peek, check out our blog post. Thanks to the many of you who have contributed to this project over the past year, and to Jeffrey and Sandy for their help as part of the editorial team. If you have any feedback or would like to submit artwork, feel free to reach out to me at any time, or catch me at SMB this week!”

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

3. Special issues

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