This week in MathOnco 231
nonheritable somatic mutations, cell barcoding, predictive modeling, antigen heterogeneity, and cell fate transitions
“This week in Mathematical Oncology” — Oct. 20, 2022
> mathematical-oncology.org
From the editor:
Today we feature articles on nonheritable somatic mutations, cell barcoding, predictive modeling, antigen heterogeneity, and cell fate transitions.
Enjoy,
Jeffrey West
jeffrey.west@moffitt.org
“Curiosity is antifragile, like an addiction, and is magnified by attempts to satisfy it— books have a secret mission and ability to multiply, as everyone who has wall-to-wall bookshelves knows well.”
— N. N. Taleb
The Adaptive Potential of Nonheritable Somatic Mutations
Paco Majic, E. Yagmur Erten, Joshua L. PayneSpatial epitope barcoding reveals clonal tumor patch behaviors
Xavier Rovira-Clavé, Alexandros P. Drainas, Sizun Jiang, Yunhao Bai, …, Garry P. NolanCellular barcoding to decipher clonal dynamics in disease
Vijay G. Sankaran, Jonathan S. Weissman, Leonard I. ZonExploring approaches for predictive cancer patient digital twins: Opportunities for collaboration and innovation
Eric A. Stahlberg, Mohamed Abdel-Rahman, Boris Aguilar, Alireza Asadpoure, …, Tanveer Syeda-Mahmood, Jinhua Wang, Qi Wang, Ioannis ZervantonakisControl of cell state transitions
Oleksii S. Rukhlenko, Melinda Halasz, Nora Rauch, Vadim Zhernovkov, Thomas Prince, Kieran Wynne, Stephanie Maher, Eugene Kashdan, Kenneth MacLeod, Neil O. Carragher, Walter Kolch, Boris N. KholodenkoInvestigating Two Modes of Cancer-Associated Antigen Heterogeneity in an Agent-Based Model of Chimeric Antigen Receptor T-Cell Therapy
Tina Giorgadze, Henning Fischel, Ansel Tessier, Kerri-Ann Norton
Data-driven spatio-temporal modelling of glioblastoma
Andreas Christ Sølvsten Jørgensen, Ciaran Scott Hill, Marc Sturrock, Wenhao Tang, Saketh R. Karamched, Dunja Gorup, Mark F. Lythgoe, Simona Parrinello, Samuel Marguerat, Vahid ShahrezaeiObserving Many Researchers Using the Same Data and Hypothesis Reveals a Hidden Universe of Uncertainty
Nate Breznau, Eike Mark Rinke, Alexander Wuttke, Muna Adem, …, Stefan Zins, Tomasz Żółtak, Hung H. V. NguyenCell division history encodes directional information of fate transitions
Kun Wang, Liangzhen Hou, Zhaolian Lu, Xin Wang, Zhike Zi, Weiwei Zhai, Xionglei He, Christina Curtis, Da Zhou, Zheng Hu
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:
Based on the paper: “The evolutionary dynamics of extrachromosomal DNA in human cancers” in Nature Genetics
Artist: Weini Huang
Caption: “Extra-chromosomal DNA (ecDNA) is circular DNA generated due to chromosomal instability during cell replication. ecDNA has a high prevalence in tumour samples. Is it a by-product or a driving force of tumour progress where cells carrying ecDNA divide faster than those without ecDNA? Because of the lack of centromeres, the segregation of ecDNA copies between two daughter cells is random, which leads to a fast evolution of ecDNA heterogeneity among cells. We validated this fundamental hypothesis of random segregation in experiments, modeled the stochastic dynamics of ecDNA, and analysed its copy number distribution over time. This leads to multiple testable predictions to distinguish positively selected from neutral ecDNA, which are validated in various tumour cell lines as well as in patient data. "
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