This week in MathOnco 235
“This week in Mathematical Oncology” — Dec. 1, 2022
From the editor:
Hope you had a great week off (Happy Thanksgiving!) — and now, back to your regularly scheduled newsletter.
Today we feature articles on evolutionary theory in cancer, fixation probability, stochastic dynamics, and a paper of our own on agent-based models.
“....genes are like the keys on a piano: although they are essential, it is the context that makes the music.”
— C. Nelson, M. Bissell
Agent-based methods facilitate integrative science in cancer
Jeffrey West, Mark Robertson-Tessi, Alexander R. A. Anderson
A hybrid spatiotemporal model of PCa dynamics and insights into optimal therapeutic strategies
Andrew Burbanks, Marianna Cerasuolo, Roberto Ronca, Leo Turner
The need for evolutionary theory in cancer research
Amy M. Boddy
More can be better: An analysis of single-mutant fixation probability functions under 2 × 2 games
Diogo L. Pires, Mark Broom
Model selection for assessing the effects of doxorubicin on triple-negative breast cancer cell lines
Anna Claudia M. Resende, Ernesto A. B. F. Lima, Regina C. Almeida, Matthew T. McKenna & Thomas E. Yankeelov
Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug–drug interaction prediction
Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy
Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes
Scott M. Leighow, Ben Landry, Michael J. Lee, Shelly R. Peyton & Justin R. Pritchard
The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease
Anna K. Miller, Ryan T. Bishop, Tao Li, Kenneth H. Shain, Niveditha Nerlakanti, Conor C. Lynch, David Basanta
Solving the stochastic dynamics of population growth
Loïc Marrec, Claudia Bank, Thibault Bertrand
Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice
Kanako Ikami, Suzanne Shoffner, Malgorzata Gosia Tyczynska Weh, Santiago Schnell, …, Shosei Yoshida, Edgar Diaz Miranda, Sooah Ko, Lei Lei
PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects
Inês G. Gonçalves, David A. Hormuth II, Sandhya Prabhakaran, Caleb M. Phillips
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:
Based on the paper: “Spatial genomics maps the structure, nature and evolution of cancer clones” in Nature
Artist: Artem Lomakin (@LomakinAI)
Caption: "When a tumour grows, mutation and selection create a mosaic of different clones. From sequencing studies, we know that such clones exist, but so far, we have not been able to see them. Here we present a method – a combination of fluorescent microscopy and mathematical modelling – that sheds light on the spatial evolution of cancer, charting the intertwined patterns of disease progression."
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Theoretical Methodology Symposium: Modelling Resistance Evolution - April 26th-28th, 2023. Application deadline: February 3rd, 2023.
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