This week in MathOnco 246

Density-dependence, evolutionary medicine, phenotypic deconvolution, convexity & game theory

“This week in Mathematical Oncology” — Mar. 16, 2023

> mathematical-oncology.org

From the editor:

Today we feature articles on density-dependence, evolutionary medicine, phenotypic deconvolution, and one of my own on convexity & game theory!

Abstract deadline extension: The MathOnc23 Phoenix conference (co-organized by Kristin Swanson & Sandy Anderson) has extended the abstract submission deadline to 3/22 (next Wednesday). There are also travel awards available!

Submit an abstract here.

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

---

“It doesn’t matter how beautiful your theory is, it doesn’t matter how smart you are. If it doesn’t agree with experiment, it’s wrong."
- R. Feynman

---

1. Inferring density-dependent population dynamics mechanisms through rate disambiguation for logistic birth-death processes
   Linh Huynh, Jacob G. Scott, Peter J. Thomas

2. The future of evolutionary medicine: sparking innovation in biomedicine and public health
   B. Natterson-Horowitz, Athena Aktipis, Molly Fox, Peter D. Gluckman, Felicia M. Low, Ruth Mace, Andrew Read, Paul E. Turner, Daniel T. Blumstein

3. Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data

   Alvaro Köhn-Luque, Even Moa Myklebust, Dagim Shiferaw Tadele, Mariaserena Giliberto, …, Jorrit M. Enserink, Kevin Leder, Arnoldo Frigessi, Jasmine Foo

4. A novel interpretable machine learning algorithm to identify optimal parameter space for cancer growth
   Helena Coggan, Helena Andres Terre, Pietro Liò

5. Abiraterone-Docetaxel scheduling for metastatic castration-resistant prostate cancer based on evolutionary dynamics
   Atefeh Deris, Mahdi Sohrabi-Haghighat

1. Games and the treatment convexity of cancer
   Péter Bayer, Jeffrey West

2. Machine-learning and mechanistic modeling of primary and metastatic breast cancer growth after neoadjuvant targeted therapy
   S. Benzekry, M. Mastri, C. Nicolò, J. ML Ebos

3. The influence of explicit local dynamics on range expansions driven by long-range dispersal
   Nathan Villiger, Jayson Paulose

4. Drift on holey landscapes as a dominant evolutionary process
   Ned A. Dochtermann, Brady Klock, Derek A. Roff, Raphaël Royauté

5. Evolution of quantitative traits under directional selection: Selective sweeps or small allele-frequency changes?
   Hannah Götsch, Reinhard Bürger

6. Exploring tumor-normal cross-talk with TranNet: role of the environment in tumor progression
   Bayarbaatar Amgalan, Chi-Ping Day, Teresa M. Przytycka

7. FitMultiCell: Simulating and parameterizing computational models of multi-scale and multi-cellular processes
   Emad Alamoudi, Yannik Schälte, Robert Müller, Jörn Starruß, Nils Bundgaard, Frederik Graw, Lutz Brusch, Jan Hasenauer

1. Breaking Barriers: Introducing The Week in Bioinformatics to the Mathematical Oncology Community
   The Mathematical Oncology Blog
   Harsha Meghadri: “Greetings from week in Bioinformatics substack, I would like to introduce you to the world of Bioinformatics before introducing myself. In one of many ways, Bioinformatics has started to make its way from its use in the sacrosanct halls of academic research to becoming a field of prevalence in everyday life. If you have heard of 23&Me or MyHeritage or ancestry and used one of their services, you have indeed ventured into the field of bioinformatics. If not, did you have a recent COVID-19 jab; especially the mRNA vaccines from BioNTech? Then you have had an encounter with bioinformatics or the product of decades-long research that had Bioinformatics as a core component.“

2. On the road to achieving work–life balance in academia
   Michelle Y. Martin, Ansley Grimes Stanfill

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the conference: MathOnco23 Phoenix

Artist: Sandy Anderson

Caption: "We are excited to announce the inaugural Mathematical Oncology Meeting in Spring 2023 (30th April - 3rd May) in Phoenix. To support the growing momentum in our field of Mathematical Oncology, we feel the time is ripe to establish a new regularly recurring (annual or bi-annual) meeting that will provide an international venue for collaboration, integration, training and synergy for our exciting fusion of disciplines. We look forward to seeing you in Phoenix to launch the next chapter in Mathematical Oncology as we leverage the power of mathematics to drive forward positive change for patients with cancer."

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

3. Special issues

---

Current subscriber count: >1.5k