This week in MathOnco 259

Antifragility, spatial analysis, resilience in dynamical systems, game theory...

“This week in Mathematical Oncology” — June 22, 2023

> mathematical-oncology.org

From the editor:

Today we feature articles on spatial analysis, resilience in dynamical systems, game theory, and one of my own preprints on antifragility.

Thanks,

Jeffrey West
jeffrey.west@moffitt.org

1. Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancer
   François Ghiringhelli, Frederic Bibeau, Laurent Greillier, Jean-David Fumet, …, Stéphane Garcia, Anne Laure Lepage, Pascale Tomasini, Jérôme Galon

2. Resilience of dynamical systems
   Hana Krakovská, Christian Kuehn, Iacopo P. Longo

3. A practical guide for the generation of model-based virtual clinical trials
   Morgan Craig, Jana L. Gevertz, Irina Kareva, Kathleen P. Wilkie

4. The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells
   Martyna Jaworska, Julia Szczudło, Adrian Pietrzyk, Jay Shah, Sonia E. Trojan, Barbara Ostrowska & Kinga A. Kocemba-Pilarczyk

5. Effects of Heterogeneity on Cancer: A Game Theory Perspective
   Annick Laruelle, André Rocha, Claudia Manini, José I. López & Elena Inarra

6. Metabolic Imaging as a Tool to Characterize Chemoresistance and Guide Therapy in Triple-Negative Breast Cancer (TNBC)
   Enakshi D. Sunassee, Bruna V. Jardim-Perassi, Megan C. Madonna, Bryce Ordway, Nirmala Ramanujam

1. A survey of CIN measures across mechanistic models
   Andrew R Lynch, Shermineh Bradford, Amber S Zhou, Kim Oxendine, Les Henderson, Vanessa L Horner, Beth A Weaver, Mark E Burkard

2. The cost of information acquisition by natural selection
   Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom

3. Second-order effects of chemotherapy pharmacodynamics and pharmacokinetics on tumor regression and cachexia
   Luke Pierik, Patricia McDonald, Alexander R. A. Anderson, Jeffrey West

4. Turning Ecology Against Pesticide Resistance: Exploiting Competition in Pest Populations Through Pesticide Use
   Rafael Dettogni Guariento, Mauricio Almeida-Gomes, Luiz Gustavo Rodrigues Oliveira-Santos, Aliny Patricia Flausino Pires, Fabio de Oliveira Roque

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the paper: Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration in eLife

Artist: Duncan Martinson (@DuncanMartinson)

Caption: "Collective cell migration is not only a hallmark of cancer but also of developmental biology. In both fields, it remains unclear how the extracellular matrix (ECM) may establish and guide cell movement. The images above depict agent-based model (ABM) simulations which investigate dynamic, reciprocal interactions between the ECM and neural crest stem cells traveling from an embryonic structure that later becomes the spinal cord. Our mathematical model, which is described here, is inspired by experimental observations that suggest neural crest cells remodel an initially punctate fibronectin matrix over the course of migration. We use the ABM to evaluate whether such remodeling allows leading cells in a neural crest stream to efficiently communicate the history of their trajectories to trailing cells. Global sensitivity analysis and simulated under/overexpression experiments reveal that contact guidance, a mechanism by which cells align themselves along ECM fibers, is essential for robust long-distance migration along target corridors. In the images, which depict two example ABM simulations, fibronectin puncta and fibers are denoted by light blue squares and arrows, respectively, while neural crest cells are depicted as red and black circles (the only difference between the two cell types is that black agents can secrete new fibronectin)."

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

• Advances in Computational Biology (NGSchool2023), Warsaw, Poland 🇵🇱, (Zuzanna Nowicka, Medical University of Lodz, Poland)

3. Special issues

• Mathematical modeling in radiotherapy and immunotherapy; Journal: Mathematical Biosciences and Engineering (Editors: David A. Hormuth, II, Guillermo Lorenzo, Joseph D. Butner, Chengyue Wu, Mohammad U. Zahid; Deadline: March 31 2024)

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