This week in MathOnco 260

Evolutionary dynamics, immune checkpoint, growth facilitation, tumor clonality, and more...

“This week in Mathematical Oncology” — July 6, 2023

> mathematical-oncology.org

From the editor:

Today we feature articles on evolutionary dynamics, immune checkpoint, growth facilitation, tumor clonality, and more...

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

1. Cell facilitation promotes growth and survival under drug pressure in breast cancer
   Rena Emond, Jason I. Griffiths, Vince Kornél Grolmusz, Aritro Nath, Jinfeng Chen, Eric F. Medina, Rachel S. Sousa, Timothy Synold, Frederick R. Adler & Andrea H. Bild

2. Relapse Timing Is Associated With Distinct Evolutionary Dynamics in Diffuse Large B-Cell Lymphoma
   Laura K. Hilton, Henry S. Ngu, Brett Collinge, …, Christian Steidl, Ryan D. Morin, David W. Scott

3. CNETML: maximum likelihood inference of phylogeny from copy number profiles of multiple samples
   Bingxin Lu, Kit Curtius, Trevor A. Graham, Ziheng Yang & Chris P. Barnes

4. Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
   Massimo Saini, Laura Schmidleitner, Helena Domínguez Moreno, …, Martin R. Sprick, Andreas Trumpp, Christina H. Scheel

5. Bernstein Polynomial Approximation of Fixation Probability in Finite Population Evolutionary Games
   Jiyeon Park & Paul K. Newton

6. Toward a systems-level probing of tumor clonality
   Emanuelle I. Grody, Ajay Abraham, Vipul Shukla, Yogesh Goyal

7. Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy
   Perrine Courlet, Daniel Abler, Monia Guidi, …, Olivier Michielin, Michel A. Cuendet, Nadia Terranova

1. Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors
   Alberto Gil-Jimenez, Nick van Dijk, Joris L. Vos, Yoni Lubeck, Maurits L. van Montfoort, Dennis Peters, Erik Hooijberg, Annegien Broeks, Charlotte L. Zuur, Bas van Rhijn, Daniel J. Vis, Michiel S. van der Heijden, Lodewyk F. A. Wessels

2. Hypoxia-related radiotherapy resistance in tumours: treatment efficacy investigation in an eco-evolutionary perspective
   Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala

3. Extended correlation functions for spatial analysis of multiplex imaging data
   Joshua A Bull, Eoghan J Mulholland, Simon J Leedham, Helen M Byrne

1. Book: Evolutionary Dynamics of Malignancy, The Genetic and Environmental Causes of Cancer
   Robert C. Jackson: “Discusses changes in pathways that drive malignant transformation. Chapters are enriched with computational models in an electronic supplement. Targeted to tumour biologists, clinicians and drug developers.”

2. Mathematical models for cancer immunotherapies
   The Mathematical Oncology Blog
   Wencel Valega Mackenzie: “Neoantigen cancer vaccination shows promise as a cancer treatment by stimulating T cells to selectively eliminate cancer cells. However, the underlying processes and mechanisms are complex. In order to describe, investigate, simulate, and forecast the response of the human immune system to a personalized cancer vaccine, our research group has developed a mechanistic mathematical model.“

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Artist: Jeffrey West

Caption: "This week's cover artwork comes from a simulation within the Lenia (from the Latin word lenis, meaning "smooth") mathematical framework. Lenia is an N-dimensional cellular automata framework which allows for a continuous representation of space and time. It was first published in 2018 by Bert Chan (@BertChakovsky). Shown here is a "multi-channel" Lenia simulation of the classic rock-paper-scissors game where red (rock) dominates blue (scissors) dominates green (paper) which dominates red again. The characteristic length scale of the rings is determined by an interaction kernel within Lenia: the function which describes the strength of competitive effects over spatial distance. Please enjoy Bert's interactive website to further explore the Lenia framework, here. Check out my Twitter thread explaining my interest in the framework, here."

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