This week in Mathematical Oncology

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This week in MathOnco 260

Evolutionary dynamics, immune checkpoint, growth facilitation, tumor clonality, and more...

Jeffrey West
,
Maximilian Strobl
,
Ryan Schenck
, and
Sandy Anderson
Jul 6, 2023
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This week in MathOnco 260

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“This week in Mathematical Oncology” — July 6, 2023
> mathematical-oncology.org
From the editor:

Today we feature articles on evolutionary dynamics, immune checkpoint, growth facilitation, tumor clonality, and more...

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

  1. Cell facilitation promotes growth and survival under drug pressure in breast cancer
    Rena Emond, Jason I. Griffiths, Vince Kornél Grolmusz, Aritro Nath, Jinfeng Chen, Eric F. Medina, Rachel S. Sousa, Timothy Synold, Frederick R. Adler & Andrea H. Bild

  2. Relapse Timing Is Associated With Distinct Evolutionary Dynamics in Diffuse Large B-Cell Lymphoma
    Laura K. Hilton, Henry S. Ngu, Brett Collinge, …, Christian Steidl, Ryan D. Morin, David W. Scott

  3. CNETML: maximum likelihood inference of phylogeny from copy number profiles of multiple samples
    Bingxin Lu, Kit Curtius, Trevor A. Graham, Ziheng Yang & Chris P. Barnes

  4. Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
    Massimo Saini, Laura Schmidleitner, Helena Domínguez Moreno, …, Martin R. Sprick, Andreas Trumpp, Christina H. Scheel

  5. Bernstein Polynomial Approximation of Fixation Probability in Finite Population Evolutionary Games
    Jiyeon Park & Paul K. Newton

  6. Toward a systems-level probing of tumor clonality
    Emanuelle I. Grody, Ajay Abraham, Vipul Shukla, Yogesh Goyal

  7. Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy
    Perrine Courlet, Daniel Abler, Monia Guidi, …, Olivier Michielin, Michel A. Cuendet, Nadia Terranova

  1. Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors
    Alberto Gil-Jimenez, Nick van Dijk, Joris L. Vos, Yoni Lubeck, Maurits L. van Montfoort, Dennis Peters, Erik Hooijberg, Annegien Broeks, Charlotte L. Zuur, Bas van Rhijn, Daniel J. Vis, Michiel S. van der Heijden, Lodewyk F. A. Wessels

  2. Hypoxia-related radiotherapy resistance in tumours: treatment efficacy investigation in an eco-evolutionary perspective
    Giulia Chiari, Giada Fiandaca, Marcello Edoardo Delitala

  3. Extended correlation functions for spatial analysis of multiplex imaging data
    Joshua A Bull, Eoghan J Mulholland, Simon J Leedham, Helen M Byrne

  1. Book: Evolutionary Dynamics of Malignancy, The Genetic and Environmental Causes of Cancer
    Robert C. Jackson: “Discusses changes in pathways that drive malignant transformation. Chapters are enriched with computational models in an electronic supplement. Targeted to tumour biologists, clinicians and drug developers.”

  2. Mathematical models for cancer immunotherapies
    The Mathematical Oncology Blog
    Wencel Valega Mackenzie: “Neoantigen cancer vaccination shows promise as a cancer treatment by stimulating T cells to selectively eliminate cancer cells. However, the underlying processes and mechanisms are complex. In order to describe, investigate, simulate, and forecast the response of the human immune system to a personalized cancer vaccine, our research group has developed a mechanistic mathematical model.“

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Artist: Jeffrey West

Caption: "This week's cover artwork comes from a simulation within the Lenia (from the Latin word lenis, meaning "smooth") mathematical framework. Lenia is an N-dimensional cellular automata framework which allows for a continuous representation of space and time. It was first published in 2018 by Bert Chan (@BertChakovsky). Shown here is a "multi-channel" Lenia simulation of the classic rock-paper-scissors game where red (rock) dominates blue (scissors) dominates green (paper) which dominates red again. The characteristic length scale of the rings is determined by an interaction kernel within Lenia: the function which describes the strength of competitive effects over spatial distance. Please enjoy Bert's interactive website to further explore the Lenia framework, here. Check out my Twitter thread explaining my interest in the framework, here."

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

2. Conferences / Meetings

3. Special issues


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