This week in MathOnco 265

tumor-immune, resistance mutations, metabolism, stroma remodeling and more

“This week in Mathematical Oncology” — August 24, 2023

> mathematical-oncology.org

From the editor:

Today we feature articles on tumor-immune, resistance mutations, metabolism, stroma remodeling and more.

Also, there are few job and conference postings at the bottom of this email — don’t miss it!

Thanks,

Jeffrey West
jeffrey.west@moffitt.org

1. The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism
   Benjamin C. S. Leow, Chung H. Kok, David T. Yeung, Timothy P. Hughes, Deborah L. White & Laura N. Eadie

2. Breast cancers as ecosystems: a metabolic perspective
   Flavia Martino, Mariadomenica Lupi, Enrico Giraudo & Letizia Lanzetti

3. Unraveling the dangerous duet between cancer cell plasticity and drug resistance
   Namrata Chatterjee, Bhavana Pulipaka, Ayalur Raghu Subbalakshmi, Mohit Kumar Jolly, Radhika Nair

4. Impact of stroma remodeling on forces experienced by cancer cells and stromal cells within pancreatic tumor tissue
   Mahsa Dabagh, Morgan Connaughton, Andrea Alonso

5. Building an adaptive dose simulation framework to aid dose and schedule selection
   Richard Hooijmaijers, Ridhi Parasrampuria, Eleonora Marostica, Geraldine Ferron-Brady, Teun M. Post, Sandra A. G. Visser

6. Evolutionary histories of breast cancer and related clones
   Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Takaki Sakurai, Tatsuki R. Kataoka, Eiji Kondoh, Yoshitsugu Chigusa, Masahiko Kawai, …, Kengo Takeuchi, Hironori Haga, Masakazu Toi & Seishi Ogawa

1. Topological classification of tumour-immune interactions and dynamics
   Jingjie Yang, Heidi Fang, Jagdeep Dhesi, Iris H.R. Yoon, Joshua A. Bull, Helen M. Byrne, Heather A. Harrington, Gillian Grindstaff

2. Relational persistent homology for multispecies data with application to the tumor microenvironment
   Bernadette J. Stolz, Jagdeep Dhesi, Joshua A. Bull, Heather A. Harrington, Helen M. Byrne, Iris H.R. Yoon

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the paper: Cell facilitation promotes growth and survival under drug pressure in breast cancer in Nature Communication

Artist: Jason Griffiths & Rena Emond (@AndreaBildLab)

Caption: “Framing cancer growth in an ecological context revealed why drug (x) sensitive cells (S: yellow) grow better when with resistant cells (R: red) than they do alone. Dynamical models of competition and facilitation were combined with fluorescence imaging and molecular assays (including single cell RNA sequencing) to clarify how resistance is transferred from resistant to sensitive cells. We revealed that resistant cancer cells amplify production of Estradiol (E), a potent growth hormone. Estradiol diffuses within the microenvironment, facilitating proliferation of otherwise sensitive cells under treatment. Blocking growth facilitation controlled the entire cancer population. This work supports the development of treatment strategies to block cooperative communications between cancer populations to more robustly control tumor growth.”

Visit the mathematical oncology page to view jobs, meetings, and special issues. We will post new additions here, but the full list can found at mathematical-oncology.org.

1. Jobs

• Tenure-Track Assistant/Associate Professor (Pharmacometrics) - UNC Chapel Hill

2. Conferences / Meetings

• AACR Special Conference in Cancer Research: Translating Cancer Evolution and Data Science: The next frontier (December 3-6)

• Translational Systems Biology: New Computational Technologies and Trial Designs for a Continuum of Personalized Therapy symposium (August 24-25)

• 29th Congress of the European Society of Biomechanics (June 30 - July 3, 2024)

3. Special issues

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