“This week in Mathematical Oncology” — August 31, 2023
> mathematical-oncology.org
From the editor:
Today’s edition features articles on resistance, microenvironment, immune suppression, and evolvability.
Enjoy,
Jeffrey West
jeffrey.west@moffitt.org
Cultivating antimicrobial resistance: how intensive agriculture ploughs the way for antibiotic resistance
Matthew Kelbrick, Elze Hesse, Siobhán O' BrienCan cancer cells inform us about the tumor microenvironment?
Geir Nævdal, Steinar EvjePhenotypic heterogeneity drives differential disease outcome in a mouse model of Triple Negative Breast Cancer
Archana P T, Sonny Ramkomuth, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha A. Varghese, Vishnu S. Jaikumar, Mohit Kumar Jolly, Alex Swarbrick, Radhika NairTumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status
Carlijn M. Lems Gerhard A. Burger Joost B. Beltman
Impact of resistance on therapeutic design: a Moran model of cancer growth
Mason Sean Lacy, Adrianne Lena JennerPredictive Digital Twin for Optimizing Patient-Specific Radiotherapy Regimens under Uncertainty in High-Grade Gliomas
Anirban Chaudhuri, Graham Pash, David A. Hormuth II, Guillermo Lorenzo, Michael Kapteyn, Chengyue Wu, Ernesto A. B. F. Lima, Thomas E. Yankeelov, Karen WillcoxEvolvability of cancer–associated genes under APOBEC3A/B selection
Joon-Hyun Song, Liliana Davalos, Thomas MacCarthy, Mehdi DamaghiPatient-specific, mechanistic models of tumor growth incorporating artificial intelligence and big data
Guillermo Lorenzo, Syed Rakin Ahmed, David A. Hormuth II, Brenna Vaughn, Jayashree Kalpathy-Cramer, Luis Solorio, Thomas E. Yankeelov, Hector GomezNon-invasive measurement of intra-tumoral fluid dynamics with localized convolutional function regression
Ryan T Woodall, Cora C Esparza, Margarita Gutova, Maosen Wang, Jessica Cunningham-Reynolds, Alexander B Brummer, Caleb Stine, Christine Brown, Jennifer M Munson, Russell C. Rockne
Treatment resistance management: a personal story of personalized medicine in oncology
Christopher Gregg, Uncharted
The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:
Based on the pre-print: Masking, maintenance and mimicry: the interplay of cell-intrinsic and cell-extrinsic effects in evolutionary games, on BioRxiv
Artist: Nick Latina
Caption: Evolution underpins the survival of a population under environmental pressure. Resistance to treatment commonly arises as a result of such evolution. In our new pre-print, we analytically examine the addition of frequency-dependent effects on evolutionary outcomes. Through the lens of experimental biology, we frame these interactions as cell-extrinsic, growth rate-modifying, ecological interactions. We characterize how such interactions can modify evolutionary trajectories and show that they can maintain, mimic, or even completely mask, the results of cell-intrinsic fitness advantages. This work has implications for the interpretation and understanding of evolution, in particular the abundance of apparently neutral evolution in cancer. The imagery synthesized with Midjourney and reflects how the interactions of two cell types can create a new emergent identity that ecologically "masks" the individuals.
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