This week in MathOnco 267

Max likelihood estimators, relapse/recurrence, contact inhibition, game theory & convexity

Jeffrey West

Franco Pradelli

Ryan Schenck

, and 2 others

Sep 08, 2023

`> mathematical-oncology.org`

`From the editor:`

This week’s issue contains papers on max likelihood estimators, relapse/recurrence, contact inhibition, and one of my own on game theory & convexity. In other news, registration is open for the IMO Workshop!

IMO Workshop:
Please consider joining us here at Moffitt for the 11th annual Integrated Mathematical Oncology Workshop. Sign up here: imo11.eventbrite.com or read more about the workshop’s history at imoworkshop.org.

Thanks,

Jeffrey West jeffrey.west@moffitt.org

Games and the Treatment Convexity of Cancer
Péter Bayer & Jeffrey West
Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation
Basil Thurakkal, Kishore Hari, Rituraj Marwaha, Sanjay Karki, Mohit K. Jolly, Tamal Das
The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
Salvador Chulián, Bernadette J. Stolz, Álvaro Martínez-Rubio, Cristina Blázquez Goñi, …, María V. Martínez Sánchez ,María Rosa, Víctor M. Pérez-García, Helen M. Byrne
A Continuation Technique for Maximum Likelihood Estimators in Biological Models
Tyler Cassidy
Agent-Based and Continuum Models for Spatial Dynamics of Infection by Oncolytic Viruses
David Morselli, Marcello Edoardo Delitala & Federico Frascoli
Modeling the Role of Immune Cell Conversion in the Tumor-Immune Microenvironment
Alexander S. Moffett, Youyuan Deng & Herbert Levine
Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma
Evgueni Jacob, Angélique Perrillat-Mercerot, Jean-Louis Palgen, Adèle L’Hostis, Nicoletta Ceres, Jean-Pierre Boissel, Jim Bosley, Claudio Monteiro & Riad Kahoul

Phenotype Control techniques for Boolean gene regulatory networks
Daniel Plaugher & David Murrugarra
Modelling Microtube Driven Invasion of Glioma
Thomas Hillen, Nadia Loy, Kevin J Painter, Ryan Thiessen
Linking discrete and continuous models of cell birth and migration
W. Duncan Martinson, Alexandria Volkening, Markus Schmidtchen, Chandrasekhar Venkataraman, José A. Carrillo

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork (it may take a few seconds for the video to load):

Based on the paper: Virtual alignment of pathology image series for multi-gigapixel whole slide images in Nature Communications.

Artists: Chandler D. Gatenbee (@cgatenbee), Alexander R.A. Anderson (@ara_anderson)

Caption: Registering whole slide image (WSI) requires finding the rigid and non-rigid transformations that align a set of histology slides. To tackle this challenge, we developed VALIS (Virtual Alignment of pathoLogy Image Series), which is available on Github, PyPi, and Dockerhub. For this cover, we warped the VALIS logo using random non-rigid transforms combined with the rigid transforms VALIS found for a collection of seven serially sliced IHC images taken from a colorectal adenoma. The animation then shows the process of "unwarping" the logo, going from tangled mess to a clean overlay, much like what is seen after a successful WSI registration. If you would like to learn more about our software, you can check out the paper here.

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