This week in MathOnco 279

Treatment resistance, cancer evolution, game theory, mathematical oncology

“This week in Mathematical Oncology” — November 23, 2023

> mathematical-oncology.org

From the editor:

Today’s edition contains some hot topics: Treatment resistance, cancer evolution, game theory, mathematical oncology.

Enjoy,

Jeffrey West
jeffrey.west@moffitt.org

1. Modelling microtube driven invasion of glioma
   Thomas Hillen, Nadia Loy, Kevin J. Painter & Ryan Thiessen

2. Cancer Evolution: A Multifaceted Affair
   Giovanni Ciriello, Luca Magnani, Sarah J. Aitken, Leila Akkari, …, Alexander Swarbrick, Giovanni Tonon, Sakari Vanharanta, Johannes Zuber

3. Overcoming chemotherapy resistance in low-grade gliomas: A computational approach
   Thibault Delobel, Luis E. Ayala-Hernández, Jesús J. Bosque, Julián Pérez-Beteta, …, Pilar Piñero, Philippe Schucht, Michael Murek, Víctor M. Pérez-García

4. Analysis of a Cancer Model and a Replicator Dynamics Proposal for Therapy
   María José Charria-Macias; Alejandra Sandoval-Carranza; Nicanor Quijano

5. Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: Understanding and implications studied with stochastic models
   H. Jonathan G. Lindström, Astrid S. de Wijn, Ran Friedman

6. Game Theory for Managing Evolving Systems: Challenges and Opportunities of Including Vector-Valued Strategies and Life-History Traits
   Maria Kleshnina, Sabrina Streipert, Joel S. Brown & Kateřina Staňková

7. Mathematical Oncology: Tumor Evolution Models (book chapter)
   Paula Nagy, Eva H. Dulf & Levente Kovacs

8. Hybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth
   Luca Messina, Rosalia Ferraro, Maria J. Peláez, Zhihui Wang, Vittorio Cristini, Prashant Dogra, Sergio Caserta

1. On minimising tumoural growth under treatment resistance
   Matthias M. Fischer, Nils Blüthgen

2. Modelling glioblastoma resistance to temozolomide. Combination of spheroid and mathematical models to simulate cellular adaptation in vitro
   Marina Pérez-Aliacar, Jacobo Ayensa-Jiménez, Teodora Ranđelović, Ignacio Ochoa, Manuel Doblaré

1. ECMTB 2024
   JULY 22 -26 | TOLEDO · SPAIN
   The European Conference on Mathematical and Theoretical Biology (ECMTB) was first held in 1991 in Grenoble, France. It was initiated by mathematicians who were interested in applying mathematical theories to biological problems. Over the years, The ECMTB conference has grown in size and scope, attracting researchers from all over the world. In addition to promoting interdisciplinary collaborations between mathematicians, biologists, physicists, and other researchers, ECMTB has also facilitated the development of new techniques and methodologies for modelling complex biological systems. Today, ECMTB is held every two years and is instrumental in advancing the field of mathematical biology and shaping the way researchers study and understand the complex mechanisms that govern life processes.

The newsletter now has a dedicated homepage where we post the cover artwork for each issue. We encourage submissions that coincide with the release of a recent paper from your group. This week’s artwork:

Based on the paper: Dynamics of Fibril Collagen Remodeling by Tumor Cells: A Model of Tumor-Associated Collagen Signatures published in Cells.

Artists: Sharan Poonja, Ana Forero Pinto, and Kasia Rejniak (@RejniakLab)

Caption: The extracellular matrix (ECM) architecture is a key stromal component that can either suppress cancer growth or enable cancer invasion. We developed a hybrid agent-based model that handles mechanical interactions between tumor cells and ECM fibril bundles. This model reproduces three distinct tumor-associated collagen signatures (TACS) observed in histology images and simulates dynamic transitions among TACSs. The gif image shows changes in the ECM fibril patterns during a cell colony growth and invasion.

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